Wei, Juan, Antzutkin, Oleg N., Filippov, Andrei V., Iuga, Dinu, Lam, Pui Yiu, Barrow, Mark P., Dupree, Ray, Brown, Steven P. and O'Connor, Peter B. (2016) Data for Hydrogen Bonding in Alzheimer’s Amyloid-β Fibrils Probed by15N{17O} REAPDOR Solid-State NMR Spectroscopy. [Dataset]
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Abstract
An exclusive label: 15N{17O} REAPDOR NMR was used to validate intermolecular C17O⋅⋅⋅H15N hydrogen bonding in Ac-Aβ(16–22)-NH2 (see scheme) and Aβ(11–25) amyloid fibrils, which are associated with Alzheimer's disease, by selectively labeling them with 17O and 15N. This method was effective for confirming the structure of these fibrils, and could be useful for a number of other biological samples.
| Item Type: | Dataset |
|---|---|
| Subjects: | Q Science > QP Physiology |
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Physics |
| Type of Data: | SIMPSON data; Bruker NMR data |
| Library of Congress Subject Headings (LCSH): | Hydrogen bonding, Amyloid, Alzheimer's disease -- Physiological aspects |
| Publisher: | University of Warwick, Departments of Physics and Chemistry |
| Official Date: | 21 March 2016 |
| Dates: | Date Event 18 March 2016 Completion 21 March 2016 Published |
| Collection date: | Date from Date to 26 October 2010 4 December 2013 |
| Status: | Not Peer Reviewed |
| Publication Status: | Published |
| Media of Output (format): | .txt .docx |
| Access rights to Published version: | Open Access (Creative Commons open licence) |
| Description: | Amyloid Hydrogen Bonding Polymorphism Evaluated by 15N{17O}REAPDOR Solid-State NMR and Ultra-High Resolution FTICR-MS All data are Bruker NMR data sets recorded by Oleg Antzutkin and Dinu Iuga |
| Date of first compliant deposit: | 21 March 2016 |
| Date of first compliant Open Access: | 6 May 2016 |
| RIOXX Funder/Project Grant: | Project/Grant ID RIOXX Funder Name Funder ID UNSPECIFIED [EPSRC] Engineering and Physical Sciences Research Council |
| Related URLs: | |
| Open Access Version: | |
| URI: | https://wrap.warwick.ac.uk/77887/ |
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