2023

Wanika, Linda, Evans, Neil D. and Chappell, Michael J. (2023) Identification of small cell lung cancer patients who are at risk of developing common serious adverse event groups with machine learning. Frontiers in Drug Safety and Regulation, 3 . p. 1267623. doi:10.3389/fdsfr.2023.1267623 ISSN 2674-0869.

Musuamba Tshinanu, Flora, Cheung, S.Y. Amy, Colin, Pieter, Davies, Elin H., Barret, Jeffrey S., Pappalardo, Francesco, Chappell, Michael J., Dogne, Jean‐Michel, Ceci, Adriana, Della Pasqua, Oscar and Rusten, Ine S. (2023) Moving towards a question‐centric approach for regulatory decision‐making in the context of drug assessment. Clinical Pharmacology & Therapeutics, 114 (1). pp. 41-50. doi:10.1002/cpt.2856 ISSN 1532-6535.

2022

Tindall, Marcus J., Chappell, Michael J. and Yates, James W.T. (2022) The ingredients for an antimicrobial mathematical modelling broth. International Journal of Antimicrobial Agents, 60 (4). 106641. doi:10.1016/j.ijantimicag.2022.106641 ISSN 0924-8579.

Thornton, Callum John, Chappell, Michael John, Evans, Neil Darren and Hardwicke, Joseph (2022) Predicting muscle excitations of the hand from kinematic data. In: 2022 IEEE 5th International Conference on Industrial Cyber-Physical Systems (ICPS), 24-26 May 2022, Coventry, United Kingdom ISBN 9781665497701. doi:10.1109/icps51978.2022.9816979

2021

Traynor, Carlos, Sahota, Tarjinder, Tomkinson, Helen, Gonzalez-Garcia, Ignacio, Evans, Neil D. and Chappell, Michael J. (2021) Imputing biomarker status from RWE datasets — a comparative study. Journal of Personalized Medicine, 11 (12). e1356. doi:10.3390/jpm11121356 ISSN 2075-4426.

Castaldo, Rossana, Chappell, M. J., Byrne, H., Innominato, Pasquale F., Hughes, S., Pescapè, A. and Pecchia, Leandro (2021) Detection of melatonin-onset in real settings via wearable sensors and artificial intelligence : a pilot study. Biomedical Signal Processing and Control, 65 . 102386. doi:10.1016/j.bspc.2020.102386 ISSN 1746-8094.

2020

Carter, Simon J., Chouhan, Bhavik, Sharma, Pradeep and Chappell, Michael J. (2020) Prediction of clinical transporter‐mediated drug–drug interactions via comeasurement of pitavastatin and eltrombopag in human hepatocyte Models. CPT: pharmacometrics & systems pharmacology, 9 (4). pp. 211-221. doi:10.1002/psp4.12505 ISSN 2163-8306.

Catherwood, Anita C., Lloyd, Adrian J., Tod, Julie A., Chauhan, Smita, Slade, Susan E., Walkowiak, Grzegorz P., Galley, Nicola F., Punekar, Avinash S., Smart, Katie, Rea, Dean, Evans, Neil D., Chappell, Michael J., Roper, David I. and Dowson, Christopher G. (2020) Substrate and stereochemical control of peptidoglycan cross-linking by transpeptidation by Escherichia coli PBP1B. Journal of the American Chemical Society, 142 (11). pp. 5034-5048. doi:10.1021/jacs.9b08822 ISSN 0002-7863.

2019

Carter, Simon J., Ferecskó, Alex S., King, Lloyd, Ménochet, Karelle, Parton, Ted and Chappell, Michael J. (2019) A mechanistic modelling approach for the determination of the mechanisms of inhibition by cyclosporine on the uptake and metabolism of atorvastatin in rat hepatocytes using a high throughput uptake method. Xenobiotica . doi:10.1080/00498254.2019.1652781 ISSN 1366-5928.

Kendrick, Felicity, Evans, Neil D., Berlanga, Oscar, Harding, Stephen J. and Chappell, Michael J. (2019) Parameter identification for a model of neonatal Fc receptor-mediated recycling of endogenous immunoglobulin G in humans. Frontiers in Immunology, 10 . doi:10.3389/fimmu.2019.00674 ISSN 1664-3224.

Villaverde, Alejandro F., Evans, Neil D., Chappell, M. J. (Michael J.) and Banga, Julio R. (2019) Input-dependent structural identifiability of nonlinear systems. IEEE Control Systems Letters, 3 (2). pp. 272-277. doi:10.1109/LCSYS.2018.2868608 ISSN 2475-1456.

Cucurull‐Sanchez, Lourdes, Chappell, Michael J., Chelliah, Vijayalakshmi, Amy Cheung, S. Y., Derks, Gianne, Penney, Mark, Phipps, Alex, Malik‐Sheriff, Rahuman S., Timmis, Jon, Tindall, Marcus J., Graaf, Piet H., Vicini, Paolo and Yates, James W. T. (2019) Best Practices to Maximize the Use and Reuse of Quantitative and Systems Pharmacology Models: Recommendations From the United Kingdom Quantitative and Systems Pharmacology Network. CPT: pharmacometrics & systems pharmacology, 8 (5). pp. 259-272. doi:10.1002/psp4.12381 ISSN 2163-8306.

2018

Bunte, Kerstin, Smith, David J., Chappell, M. J. (Michael J.), Hassan-Smith, Zaki K., Tomlinson, Jeremy W., Arlt, Wiebke and Tiňo, Peter (2018) Learning pharmacokinetic models for in vivo glucocorticoid activation. Journal of Theoretical Biology, 455 . pp. 222-231. doi:10.1016/j.jtbi.2018.07.025 ISSN 0022-5193.

Villaverde, Alejandro F., Evans, Neil D., Chappell, Michael J. and Banga, Julio R. (2018) Sufficiently exciting inputs for structurally identifiable systems biology models. IFAC-PapersOnLine, 51 (19). pp. 16-19. doi:10.1016/j.ifacol.2018.09.015 ISSN 2405-8963.

2017

Janzén, David, Jirstrand, Mats, Chappell, M. J. (Michael J.) and Evans, Neil D. (2017) Extending existing structural identifiability analysis methods to mixed-effects models. Mathematical Biosciences, 295 . pp. 1-10. doi:10.1016/j.mbs.2017.10.009 ISSN 0025-5564.

Bergenholm, Linnéa, Parkinson, J., Mettetal, J., Evans, Neil D., Chappell, M. J. and Collins, T. (2017) Predicting QRS and PR interval prolongations in humans using nonclinical data. British Journal of Pharmacology, 174 (19). pp. 3268-3283. doi:10.1111/bph.13940 ISSN 1476-5381.

Trägårdh, Magnus, Chappell, M. J. (Michael J.), Palm, Johan E., Evans, Neil D., Janzén, David and Gennemark, Peter (2017) Input estimation for extended-release formulations exemplified with exenatide. Frontiers in Bioengineering and Biotechnology , 5 . doi:10.3389/fbioe.2017.00024 ISSN 2296-4185.

Wong, Hin Kwan, Tiffin, Paul A., Chappell, Michael J., Nichols, Thomas E., Welsh, Patrick R., Doyle, Orla M., Lopez Kolkovska, Boryana Cristina, Inglis, Sarah K., Coghill, David, Shen, Yuan and Tiño, Peter (2017) Personalized medication response prediction for attention-deficit hyperactivity disorder : learning in the model space vs. learning in the data space. Frontiers in Physiology, 8 . 199. doi:10.3389/fphys.2017.00199 ISSN 1664-042X.

Kendrick, Felicity, Evans, Neil D., Arnulf, Bertrand, Avet-Loiseau, Hervé, Decaux, Olivier, Dejoie, Thomas, Fouquet, Guillemette, Guidez, Stéphanie, Harel, Stéphanie, Hebraud, Benjamin, Javaugue, Vincent, Richez, Valentine, Schraen, Susanna, Touzeau, Cyrille, Moreau, Philippe, Leleu, Xavier, Harding, Stephen and Chappell, Michael J. (2017) Analysis of a compartmental model of endogenous immunoglobulin G metabolism with application to multiple myeloma. Frontiers in Physiology, 8 . 149. doi:10.3389/fphys.2017.00149 ISSN 1664-042X.

Chatzistefani, Nefeli, Chappell, M. J. (Michael J.), Hutchinson, Charles E., Kletzenbauer, S. and Evans, Neil D. (2017) A mathematical model characterising Achilles tendon dynamics in flexion. Mathematical Biosciences, 284 . pp. 92-107. doi:10.1016/j.mbs.2016.11.006 ISSN 0025-5564.

2016

Janzén, David, Bergenholm, Linnéa, Jirstrand, Mats, Parkinson, Joanna, Yates, James, Evans, Neil D. and Chappell, Michael J. (2016) Parameter identifiability of fundamental pharmacodynamic models. Frontiers in Physiology, 7 . 590. doi:10.3389/fphys.2016.00590 ISSN 1664-042X.

Janzén, David, Jirstrand, Mats, Chappell, M. J. (Michael J.) and Evans, Neil D. (2016) Three novel approaches to structural identifiability analysis in mixed-effects models. Computer Methods and Programs in Biomedicine . doi:10.1016/j.cmpb.2016.04.024 ISSN 0169-2607.

Bergenholm, Linnéa, Collins, Teresa, Evans, Neil D., Chappell, M. J. (Michael J.) and Parkinson, Joanna (2016) PKPD modelling of PR and QRS intervals in conscious dogs using standard safety pharmacology data. Journal of Pharmacological and Toxicological Methods, 79 . pp. 34-44. doi:10.1016/j.vascn.2016.01.002 ISSN 1056-8719.

Boger, Elin, Evans, Neil D., Chappell, M. J. (Michael J.), Lundqvist, A., Ewing, P., Wigenborg, A. and Friden, M. (2016) Systems pharmacology approach for prediction of pulmonary and systemic pharmacokinetics and receptor occupancy of inhaled drugs. CPT : Pharmacometrics & Systems Pharmacology, 5 (4). pp. 201-210. doi:10.1002/psp4.12074 ISSN 2163-8306.

Trägårdh, Magnus, Chappell, M. J. (Michael J.), Ahnmark, Andrea, Lindén, Daniel, Evans, Neil D. and Gennemark, Peter (2016) Input estimation for drug discovery using optimal control and Markov chain Monte Carlo approaches. Journal of Pharmacokinetics and Pharmacodynamics, 43 (2). pp. 207-221. doi:10.1007/s10928-016-9467-z ISSN 1567-567X.

Andersson, Robert, Jirstrand, Mats, Peletier, Lambertus, Chappell, M. J. (Michael J.), Evans, Neil D. and Gabrielsson, Johan (2016) Dose–response-time modelling : second-generation turnover model with integral feedback control. European Journal of Pharmaceutical Sciences, 81 . pp. 189-200. doi:10.1016/j.ejps.2015.10.018 ISSN 0928-0987.

2015

Janzén, David, Jirstrand, Mats, Evans, Neil D. and Chappell, M. J. (Michael J.) (2015) Structural identifiability in mixed-effects models : two different approaches. IFAC-PapersOnLine, 48 (20). pp. 563-568. doi:10.1016/j.ifacol.2015.10.201 ISSN 2405-8963.

Collins, Teresa, Bergenholm, Linnéa, Abdulla, Tariq, Yates, J. W. T., Evans, Neil D., Chappell, M. J. (Michael J.) and Mettetal, J. T. (2015) Modeling and simulation approaches for cardiovascular function and their role in safety assessment. CPT : Pharmacometrics & Systems Pharmacology, 4 (3). pp. 175-188. doi:10.1002/psp4.18 ISSN 2163-8306.

Boger, Elin, Ewing, P., Eriksson, U. G., Fihn, B.-M., Chappell, M. J. (Michael J.), Evans, Neil D. and Friden, M. (2015) A novel in vivo receptor occupancy methodology for the glucocorticoid receptor : towards an improved understanding of lung PK/PD. Journal of Pharmacology and Experimental Therapeutics, 353 (2). pp. 279-287. doi:10.1124/jpet.114.221226 ISSN 1521-0103.

2014

Vincent, Timothy A., Wilson, A., Hattersley, John G., Chappell, M. J. (Michael J.) and Gardner, J. W. (2014) Design and modelling of a portable breath analyser for metabolic rate measurement. Procedia Engineering, Volume 87 . pp. 668-671. doi:10.1016/j.proeng.2014.11.576

Braddick, Darren, Sandhu, Sandeep, Roper, David I., Chappell, M. J. (Michael J.) and Bugg, Tim (2014) Observation of the time-course for peptidoglycan lipid intermediate II polymerization by Staphylococcus aureus monofunctional transglycosylase. Microbiology, Volume 160 (Part 8). pp. 1628-1636. doi:10.1099/mic.0.079442-0 ISSN 1350-0872.

Grandjean, Thomas R. B., Chappell, M. J. (Michael J.), Yates, James W. T. and Evans, Neil D. (2014) Structural identifiability analyses of candidate models for in vitro Pitavastatin hepatic uptake. Computer Methods and Programs in Biomedicine, Volume 114 (Number 3). e60-e69. doi:10.1016/j.cmpb.2013.06.013 ISSN 0169-2607.

2013

Hall, Adam J., Chappell, M. J. (Michael J.), Aston, John A. D. and Ward, Stephen A. (2013) Pharmacokinetic modelling of the anti-malarial drug artesunate and its active metabolite dihydroartemisinin. Computer Methods and Programs in Biomedicine . doi:10.1016/j.cmpb.2013.05.010 ISSN 0169-2607.

Hattersley, John G., Chappell, M. J. (Michael J.), Zehnder, Daniel, Higgins, Rob and Evans, Neil D. (2013) Describing the effectiveness of immunosuppression drugs and apheresis in the treatment of transplant patients. Computer Methods and Programs in Biomedicine, Volume 109 (Number 2). pp. 126-133. doi:10.1016/j.cmpb.2011.12.013 ISSN 0169-2607.

Bearup, Daniel J., Evans, Neil D. and Chappell, M. J. (Michael J.) (2013) The input–output relationship approach to structural identifiability analysis. Computer Methods and Programs in Biomedicine, Volume 109 (Number 2). pp. 171-181. doi:10.1016/j.cmpb.2012.10.012 ISSN 0169-2607.

Evans, Neil D., Moyse, Harry, Lowe, David Philip, Briggs, D., Higgins, Rob, Mitchell, Daniel A., Zehnder, Daniel and Chappell, M. J. (Michael J.) (2013) Structural identifiability of surface binding reactions involving heterogeneous analyte : application to surface plasmon resonance experiments. Automatica, Volume 49 (Number 1). pp. 48-57. doi:10.1016/j.automatica.2012.09.015 ISSN 0005-1098.

2012

Grandjean , T. R., Yates, J. T. W. and Chappell, M. J. (Michael J.) (2012) Compartmental modelling of in vivo drug interaction in hepatic uptake. In: PKUK Conference 2012, Nov 2012. Published in: Pharmacokinetics UK (PKUK) (Unpublished)

Moyse, Harry, Lowe, David Philip, Briggs, D., Higgins, Rob, Bentall, A., Ball, S., Mitchell, Daniel A., Chappell, M. J. (Michael J.), Zehnder, Daniel and Evans, Neil D. (2012) Estimation of antibody binding affinities with surface plasmon resonance experiments in incompatible blood type renal transplants. In: 8th IFAC Symposium on Biological and Medical Systems, Budapest, Hungary, 29-31 Aug 2012. Published in: Biological and Medical Systems, Volume 8 (Number 1). pp. 97-102. ISBN 9783902823106. doi:10.3182/20120829-3-HU-2029.00088 ISSN 1474-6670.

Keir, R., Evans, Neil D., Hutchison, C. A., Vigano, M. R., Stella, A., Fabbrini, P., Storr, M. and Chappell, M. J. (Michael J.) (2012) Kinetic modelling of haemodialysis removal of myoglobin in rhabdomyolysis patients. In: 8th IFAC Symposium on Biological and Medical Systems, Budapest, Hungary, 29-31 Aug 2012. Published in: Biological and Medical Systems, Volume 8 (Number 1). pp. 284-289. ISBN 9783902823106. doi:10.3182/20120829-3-HU-2029.00057 ISSN 1474-6670.

Grandjean, Thomas R. B., Chappell, M. J. (Michael J.), Yates, J. T. W. and Evans, Neil D. (2012) Structural identifiability and indistinguishability analyses of in vitro pitavastatin hepatic uptake. In: 8th IFAC Symposium on Biological and Medical Systems, Budapest, Hungary, 29-31 Aug 2012. Published in: Biological and Medical Systems, Volume 8 (Number 1). pp. 361-366. doi:10.3182/20120829-3-HU-2029.00087 ISSN 1474-6670.

2011

Grandjean, Thomas R. B., Chappell, M. J. (Michael J.), Yates, J. W. T., Jones, Kevin, Wood, Gemma and Coleman, Tanya (2011) Compartmental modelling of the pharmacokinetics of a breast cancer resistance protein. Computer Methods and Programs in Biomedicine, Vol.104 (No.2). pp. 81-92. doi:10.1016/j.cmpb.2010.08.018 ISSN 0169-2607.

Atari, M. I., Chappell, M. J. (Michael J.), Errington, Rachel J., Smith, Paul J. and Evans, Neil D. (2011) Kinetic modelling of the role of the aldehyde dehydrogenase enzyme and the breast cancer resistance protein in drug resistance and transport. Computer Methods and Programs in Biomedicine, Vol.104 (No.2). pp. 93-103. doi:10.1016/j.cmpb.2010.06.008 ISSN 01692607.

Chin, Sze Vone and Chappell, M. J. (Michael J.) (2011) Structural identifiability and indistinguishability analyses of the minimal model and a euglycemic hyperinsulinemic clamp model for glucose–insulin dynamics. Computer Methods and Programs in Biomedicine, Volume 104 (Number 2). pp. 120-134. doi:10.1016/j.cmpb.2010.08.012 ISSN 0169-2607.

Chapman, James D., Chappell, M. J. (Michael J.) and Evans, Neil D. (2011) The use of a formal sensitivity analysis on epidemic models with immune protection from maternally acquired antibodies. Computer Methods and Programs in Biomedicine, Vol.104 (No.2). pp. 37-49. doi:10.1016/j.cmpb.2010.08.019 ISSN 01692607.

Watson, E. M., Chappell, M. J. (Michael J.), Ducrozet, F., Poucher, S. M. and Yates, J. W. T. (2011) A new general glucose homeostatic model using a proportional-integral-derivative controller. Computer Methods and Programs in Biomedicine, Vol.102 (No.2). pp. 119-129. doi:10.1016/j.cmpb.2010.08.013 ISSN 0169-2607.

Grandjean, Thomas R. B., Lench, A., Yates, J. W. T., Chappell, M. J. (Michael J.) and O’Donnell, C. J. (2011) Experimental and mathematical analysis of pitavastatin hepatic uptake across species. In: Pharmacokinetics UK 2011 Meeting, Durham, 9-11 Nov 2011

Hattersley, John G., Pérez-Velázquez, J., Chappell, M. J. (Michael J.), Bearup, Daniel James, Roper, David I., Dowson, Christopher G., Bugg, Tim and Evans, Neil D. (2011) Indistinguishability and identifiability of kinetic models for the MurC reaction in peptidoglycan biosynthesis. Computer Methods and Programs in Biomedicine, Vol.104 (No.2). pp. 70-80. doi:10.1016/j.cmpb.2010.07.009 ISSN 01692607.

2010

White, L. J., Schukken, Y. H., Dogan, Belgin, Green, Laura E., Döpfer, Dörte, Chappell, M. J. (Michael J.) and Medley, Graham (2010) Modelling the dynamics of intramammary E. coli infections in dairy cows: understanding mechanisms that distinguish transient from persistent infections. Veterinary Research, Vol.41 (No.2). 15 pages. doi:10.1051/vetres/2009061 ISSN 0928-4249.

Zajarias-Fainsod, Daniel, Chappell, M. J. (Michael J.), Collingwood, Joanna F., Rennie, Adam, Nagaraja, Sanjoy and Wilson, Adrian J. (2010) Patient-specific modelling of blood-flow in cerebral aneurysms. In: COMSOL Conference (2010), Boston, U.S.A, Nov 17-19, 2010. Published in: Proceedings of the COMSOL Conference 2010

Atari, M. I., Chappell, M. J. (Michael J.), Errington, Rachel J., Smith, Paul J. and Evans, Neil D. (2010) A coupled kinetic-dynamic model characterising cell cycle response to an anti-cancer agent. In: 8th Central European Symposium on Pharmaceutical Technology , Graz, Austria, Sep 16 - 18, 2010. Published in: Scientia Pharmaceutica , Vol.78 (No.3). p. 718. doi:10.3797/scipharm.cespt.8.POT03 ISSN 0036-8709.

Stovin, V. R., Guymer, I., Chappell, M. J. (Michael J.) and Hattersley, John G. (2010) The use of deconvolution techniques to identify the fundamental mixing characteristics of urban drainage structures. Water Science and Technology, Vol.61 (No.8). pp. 2075-2081. doi:10.2166/wst.2010.134 ISSN 0273-1223.

2009

Yates, James W. T., Evans, Neil D. and Chappell, M. J. (Michael J.) (2009) Structural identifiability analysis via symmetries of differential equations. Automatica, Vol.45 (No.11). pp. 2585-2591. doi:10.1016/j.automatica.2009.07.009 ISSN 0005-1098.

Atari, M. I., Chappell, M. J. (Michael J.), Errington, Rachel J., Smith, Paul J. and Evans, Neil D. (2009) Compartmental modelling of the breast cancer resistance protein (BCRP/ABCG2) in drug transport. In: The 9th International Conference on Systems Biology (ICSB2008), Gothenburg, Sweden, Aug 22-28, 2008. Published in: 9th International Conference on Systems Biology 2008 (ICSB 2008): Abstract Book

Bearup, Daniel James, Evans, Neil D., Dowson, Christopher G. and Chappell, M. J. (Michael J.) (2009) Use of structural identifiability analysis to inform experimental design for enzyme kinetics. In: The 9th International Conference on Systems Biology (ICSB2008), Gothenburg, Sweden, Aug 22-28, 2008. Published in: 9th International Conference on Systems Biology 2008 (ICSB 2008): Abstract Book

Watson, E. M., Poucher, S. M., Chappell, M. J. (Michael J.) and Teague, J. (2009) Short term and long term disease mathematical modelling of diabetes in Zucker and ZDF rats. In: 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Vienna, Austria, September 30-October 02, 2009. Published in: Diabetologia, Vol.52 (Suppl. 1). S240-S240. ISSN 0012-186X.

Hattersley, John G., Evans, Neil D., Chappell, M. J. (Michael J.), Mead, Graham P. and Hutchison, Colin A. (2009) Nonparametric prediction of free-light chain generation in multiple myeloma patients. In: 17th International Federation of Automatic Control World Congress (IFAC), Seoul, Republic of Korea, Jul 6-11, 2008. Published in: Proceedings of the 17th IFAC World Congress, 2008, Vol.17 (Part 1). pp. 8091-8096. doi:10.3182/20080706-5-KR-1001.01366 ISSN 1474-6670.

Pérez-Velázquez, J., Evans, Neil D., Chappell, M. J. (Michael J.), Errington, R, Smith, Paul J. and Khan, I. (2009) A mathematical model of cyclin B1 dynamics at the single cell level in osteosarcoma cells. In: 17th International Federation of Automatic Control World Congress (IFAC), Seoul, Republic of Korea, Jul 6-11, 2008. Published in: Proceedings of the 17th IFAC World Congress, 2008, Vol.17 (Part 1). pp. 9057-9062. doi:10.3182/20080706-5-KR-1001.01529 ISSN 1474-6670.

Hutchison, Colin A., Bradwell, Arthur R., Cook, Mark, Basnayake, Kolitha, Basu, Supratik, Harding, Stephen, Hattersley, John G., Evans, Neil D., Chappell, M. J. (Michael J.), Sampson, Paul, Foggensteiner, Lukas, Adu, Dwomoa and Cockwell, Paul (2009) Treatment of acute renal failure secondary to multiple myeloma with chemotherapy and extended high cut-off hemodialysis. Clinical Journal of the American Society of Nephrology, Vol.4 (No.4). pp. 745-754. doi:10.2215/CJN.04590908 ISSN 1555-9041.

Grandjean, Thomas R. B., Chappell, M. J. (Michael J.), Yates, James, Jones, Kevin, Coleman, Tanya and Wood, Gemma (2009) Compartmental modelling of the pharmacokinetics of a breast cancer resistance protein. In: 7th IFAC Symposium on Modelling and Control in Biomedical Systems, Hvide Hus, Denmark. Published in: Modeling and Control in Biomedical Systems, 7 (1). pp. 115-120. doi:10.3182/20090812-3-DK-2006.00020 ISSN 1474-6670.

2008

Cheung, S. Y. Amy, Evans, Neil D., Chappell, M. J. (Michael J.), Godfrey, Keith, Smith, Paul J. and Errington, Rachel J. (2008) Exploration of the intercellular heterogeneity of topotecan uptake into human breast cancer cells through compartmental modelling. Mathematical Biosciences, Vol.213 (No.2). pp. 119-134. doi:10.1016/j.mbs.2008.03.008 ISSN 0025-5564.

Chappell, M. J. (Michael J.), Evans, Neil D., Errington, Rachel J., Khan, I. A., Campbell, L., Ali, Reza, Godfrey, Keith and Smith, Paul J. (2008) A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan. Computer Methods and Programs in Biomedicine, Vol.89 (No.2). pp. 169-178. doi:10.1016/j.cmpb.2007.11.002 ISSN 0169-2607.

Evans, Neil D. and Chappell, M. J. (Michael J.) (2008) Observability normal form approach to structural identifiability analysis: application to biomedical systems models. In: European Conference on Mathematical and Theoretical Biology (ECMTB08), Edinburgh, Scotland, June 29 - July 4, 2008

2007

Hutchison, Colin A., Cook, Mark, Harding, Stephen, Mead, Graham, Hattersley, John G., Evans, Neil D., Chappell, M. J. (Michael J.), Cockwell, Paul and Bradwell, Arthur (2007) Mathematical modelling of free light chain removal by plasma exchange and extended hemodialysis in patients with cast nephropathy. In: Spring Clinical Meeting of the National-Kidney-Foundation, Orlando, FL, April 10-14, 2007. Published in: American Journal of Kidney Diseases, Vol.49 (No.4). B46-B46. ISSN 0272-6386.

Hutchison, Colin A., Cockwell, Paul, Reid, Steven, Chandler, Katie, Mead, Graham P., Harrison, John, Hattersley, John G., Evans, Neil D., Chappell, M. J. (Michael J.), Cook, Mark, Goehl, Hermann, Storr, Markus and Bradwell, Arthur R. (2007) Efficient removal of immunoglobulin free light chains by hemodialysis for multiple myeloma: in vitro and in vivo studies. Journal of the American Society of Nephrology, Vol.18 (No.3). pp. 886-895. doi:10.1681/ASN.2006080821 ISSN 1046-6673.

Yates, James W. T., Chappell, M. J. (Michael J.) and Gardner, J. W. (2007) Novel phenomena-based dynamic model of carbon black/composite vapour sensors. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol.463 (No.2078). pp. 551-568. doi:10.1098/rspa.2006.1776 ISSN 1364-5021.

Ali, Reza, Evans, Neil D., Campbell, Lee, Errington, Rachel J., Godfrey, Keith R., Smith, Paul J. and Chappell, M. J. (Michael J.) (2007) Modelling the control of cell proliferation by an anti-cancer agent. Measurement & Control, Vol.40 (No.1). pp. 12-15. ISSN 0020-2940.

2006

Hutchison, Colin A., Cockwell, Paul, Reid, Steven, Chandler, Katie, Mead, Graham P., Harrison, John, Hattersley, John G., Evans, Neil D., Chappell, M. J. (Michael J.), Cook, Mark, Goehl, Hermann, Storr, Markus and Bradwell, Arthur R. (2006) Efficient removal of immunoglobulin free light chains by hemodialysis in multiple myeloma: In-vitro and in-vivo studies. In: 48th Annual Meeting of the American-Society-of-Hematology, Orlando, FL, DEC 09-12, 2006. Published in: BLOOD, 108 (11 Part 2). 367B-368B. ISSN 0006-4971.

Hutchison, C. A., Cockwell, P., Reid, S. D., Chandler, K. L., Millard, J. L., Mead, G. P., Evans, Neil D., Chappell, M. J. (Michael J.) and Bradwell, A. R. (2006) Removal of serum free light chains by hemodialysis in patients with multiple myeloma. In: 58th Annual Meeting of the American-Association-of-Clinical-Chemistry, Chicago, IL, JUL 23-27, 2006. Published in: Clinical Chemistry, Volume 52 (Number 6 Suppl. S). A27-A27. ISSN 0009-9147.

White, L. J., Lam, T. J. G. M., Schukken, Y. H., Green, Laura E., Medley, Graham and Chappell, M. J. (Michael J.) (2006) The transmission and control of mastitis in dairy cows: A theoretical approach. In: Meeting of the Society for Veterinary Epidemiology and Preventive Medicine, Warwick, England, 2003. Published in: Preventive Veterinary Medicine, Vol.74 (No.1). pp. 67-83. doi:10.1016/j.prevetmed.2006.01.008 ISSN 0167-5877.

2005

Yates, J. W. T., Gardner, J. W., Dow, Crawford S. and Chappell, M. J. (Michael J.) (2005) Identification of bacterial pathogens using quadrupole mass spectrometer data and radial basis function neural networks. IEE Proceedings - Science, Measurement and Technology, 152 (3). pp. 97-102. doi:10.1049/ip-smt:20041145 ISSN 1350-2344.

2003

Yates, J. W. T., Gardner, J. W., Chappell, M. J. (Michael J.), Bolt, F., Beeby, L. and Dowson, Christopher G. (2003) Chemical sensor screening of blood samples : robust analysis via data set reduction. In: 5th IFAC Symposium on Modelling and Control in Biomedical Systems, Melbourne, Australia, 21-23 Aug 2003. Published in: Modellling and Control in Biomedical Systems 2003 (including Biology Systems) pp. 289-294. ISBN 0080441599. ISSN 0962-9505.

2001

White, L. J., Schukken, Y. H., Lam, T. J. G. M., Medley, Graham and Chappell, M. J. (Michael J.) (2001) A multispecies model for the transmission and control of mastitis in dairy cows. Epidemiology and Infection, Vol.127 (No.3). pp. 567-576. doi:10.1017/S0950268801006100 ISSN 0950-2688.

1987

Chappell, M. J. (Michael J.) (1987) Lyapunov exponents for certain stochastic flows. PhD thesis, University of Warwick.