2017

Trägårdh, Magnus, Chappell, Michael J., Palm, Johan E., Evans, Neil D., Janzén , David and Gennemark, Peter. (2017) Input estimation for extended-release formulations exemplified with exenatide. Frontiers in Bioengineering and Biotechnology , 5 . ISSN 2296-4185

Wong, Hin Kwan, Tiffin, Paul A., Chappell, Michael J., Nichols, Thomas E., Welsh, Patrick R., Doyle, Orla M., Lopez-Kolkovska, Boryana C., Inglis, Sarah K., Coghill, David, Shen, Yuan and Tiño, Peter. (2017) Personalized medication response prediction for attention-deficit hyperactivity disorder : learning in the model space vs. learning in the data space. Frontiers in Physiology, 8 . 199. ISSN 1664-042X

Kendrick, Felicity, Evans, Neil D., Arnulf, Bertrand, Avet-Loiseau, Hervé, Decaux, Olivier, Dejoie, Thomas, Fouquet, Guillemette, Guidez, Stéphanie, Harel, Stéphanie, Hebraud, Benjamin, Javaugue, Vincent, Richez, Valentine, Schraen, Susanna, Touzeau, Cyrille, Moreau, Philippe, Leleu, Xavier, Harding, Stephen and Chappell, Michael J.. (2017) Analysis of a compartmental model of endogenous immunoglobulin G metabolism with application to multiple myeloma. Frontiers in Physiology, 8 . 149. ISSN 1664-042X

2016

Janzén , David, Bergenholm, Linnéa, Jirstrand, Mats, Parkinson, Joanna, Yates, James, Evans, Neil D. and Chappell, M. J. (Michael J.). (2016) Parameter identifiability of fundamental pharmacodynamic models. Frontiers in Physiology, 7 . 590. ISSN 1664-042X

Chatzistefani, Nefeli, Chappell, M. J. (Michael J.), Hutchinson, C., Kletzenbauer, S. and Evans, N. D.. (2016) A mathematical model characterising Achilles tendon dynamics in flexion. Mathematical Biosciences . ISSN 0025-5564 (In Press)

Janzén , David, Jirstrand, Mats, Chappell, M. J. (Michael J.) and Evans, Neil D.. (2016) Three novel approaches to structural identifiability analysis in mixed-effects models. Computer Methods and Programs in Biomedicine . ISSN 0169-2607

Bergenholm, Linnéa, Collins, Teresa, Evans, Neil D., Chappell, M. J. and Parkinson, Joanna. (2016) PKPD modelling of PR and QRS intervals in conscious dogs using standard safety pharmacology data. Journal of Pharmacological and Toxicological Methods, 79 . pp. 34-44. ISSN 1056-8719

Boger, Elin, Evans, N. D., Chappell, M. J. (Michael J.), Lundqvist, A., Ewing, P., Wigenborg, A. and Friden, M.. (2016) Systems pharmacology approach for prediction of pulmonary and systemic pharmacokinetics and receptor occupancy of inhaled drugs. CPT : Pharmacometrics & Systems Pharmacology, 5 (4). pp. 201-210. ISSN 2163-8306

Trägårdh, Magnus, Chappell, Michael J., Ahnmark, Andrea, Lindén, Daniel, Evans, Neil D. and Gennemark, Peter. (2016) Input estimation for drug discovery using optimal control and Markov chain Monte Carlo approaches. Journal of Pharmacokinetics and Pharmacodynamics, 43 (2). pp. 207-221. ISSN 1567-567X

2015

Janzén , David, Jirstrand, Mats, Evans, Neil D. and Chappell, M. J.. (2015) Structural identifiability in mixed-effects models : two different approaches. IFAC-PapersOnLine, 48 (20). pp. 563-568. ISSN 2405-8963

Boger, E., Ewing, P., Eriksson, U. G., Fihn, B.-M., Chappell, M. J. (Michael J.), Evans, N. D. and Friden, M.. (2015) A novel in vivo receptor occupancy methodology for the glucocorticoid receptor : towards an improved understanding of lung PK/PD. Journal of Pharmacology and Experimental Therapeutics . ISSN 1521-0103 (In Press)

2014

Vincent, Timothy A., Wilson, A., Hattersley, J. G., Chappell, M. J. and Gardner, J. W. (2014) Design and modelling of a portable breath analyser for metabolic rate measurement. Procedia Engineering, Volume 87 . pp. 668-671. ISSN 1877-7058

Braddick, Darren, Sandhu, Sandeep, Roper, David I., Chappell, M. J. and Bugg, Tim. (2014) Observation of the time-course for peptidoglycan lipid intermediate II polymerization by Staphylococcus aureus monofunctional transglycosylase. Microbiology, Volume 160 (Part 8). pp. 1628-1636. ISSN 1350-0872

Grandjean, Thomas R. B., Chappell, M. J., Yates, James W. T. and Evans, N. D.. (2014) Structural identifiability analyses of candidate models for in vitro Pitavastatin hepatic uptake. Computer Methods and Programs in Biomedicine, Volume 114 (Number 3). e60-e69. ISSN 0169-2607

2013

Hall, Adam J., Chappell, M. J. (Michael J.), Aston, John A. D. and Ward, Stephen A.. (2013) Pharmacokinetic modelling of the anti-malarial drug artesunate and its active metabolite dihydroartemisinin. Computer Methods and Programs in Biomedicine . ISSN 0169-2607

Hattersley, J. G. (John G.), Chappell, M. J. (Michael J.), Zehnder, Daniel, Higgins, R. M. and Evans, N. D.. (2013) Describing the effectiveness of immunosuppression drugs and apheresis in the treatment of transplant patients. Computer Methods and Programs in Biomedicine, Volume 109 (Number 2). pp. 126-133. ISSN 0169-2607

Bearup, Daniel J., Evans, N. D. and Chappell, M. J.. (2013) The input–output relationship approach to structural identifiability analysis. Computer Methods and Programs in Biomedicine, Volume 109 (Number 2). pp. 171-181. ISSN 0169-2607

Evans, N. D., Moyse, H. A. J. , Lowe, David Philip, Briggs, D., Higgins, R., Mitchell, Daniel Anthony, Zehnder, Daniel and Chappell, M. J. (Michael J.). (2013) Structural identifiability of surface binding reactions involving heterogeneous analyte : application to surface plasmon resonance experiments. Automatica, Volume 49 (Number 1). pp. 48-57. ISSN 0005-1098

2012

Grandjean , T. R., Yates, J. T. W. and Chappell, M. J. (Michael J.) (2012) Compartmental modelling of in vivo drug interaction in hepatic uptake. In: PKUK Conference 2012, Nov 2012. Published in: Pharmacokinetics UK (PKUK) (Unpublished)

Moyse, H. A. J. , Lowe, David, Briggs, D., Higgins, R., Bentall, A., Ball, S., Mitchell, Daniel Anthony, Chappell, M. J. (Michael J.), Zehnder, Daniel and Evans, N. D. (2012) Estimation of antibody binding affinities with surface plasmon resonance experiments in incompatible blood type renal transplants. In: 8th IFAC Symposium on Biological and Medical Systems, Budapest, Hungary, 29-31 Aug 2012. Published in: Biological and Medical Systems, Volume 8 (Number 1). pp. 97-102.

Keir, R., Evans, N. D., Hutchison, C. A., Vigano, M. R., Stella, A., Fabbrini, P., Storr, M. and Chappell, M. J. (Michael J.) (2012) Kinetic modelling of haemodialysis removal of myoglobin in rhabdomyolysis patients. In: 8th IFAC Symposium on Biological and Medical Systems, Budapest, Hungary, 29-31 Aug 2012. Published in: Biological and Medical Systems, Volume 8 (Number 1). pp. 284-289.

Grandjean, Thomas R. B., Chappell, M. J. (Michael J.), Yates, J. T. W. and Evans, N. D. (2012) Structural identifiability and indistinguishability analyses of in vitro pitavastatin hepatic uptake. In: 8th IFAC Symposium on Biological and Medical Systems, Budapest, Hungary, 29-31 Aug 2012. Published in: Biological and Medical Systems, Volume 8 (Number 1). pp. 361-366.

2011

Grandjean, Thomas R. B., Chappell, M. J. (Michael J.), Yates, J. W. T., Jones, Kevin, Wood, Gemma and Coleman, Tanya (2011) Compartmental modelling of the pharmacokinetics of a breast cancer resistance protein. Computer Methods and Programs in Biomedicine, Vol.104 (No.2). pp. 81-92. ISSN 0169-2607

Atari, M. I., Chappell, M. J., Errington, Rachel J., Smith, Paul J. and Evans, N. D.. (2011) Kinetic modelling of the role of the aldehyde dehydrogenase enzyme and the breast cancer resistance protein in drug resistance and transport. Computer Methods and Programs in Biomedicine, Vol.104 (No.2). pp. 93-103. ISSN 01692607

Chin, Sze Vone and Chappell, M. J. (Michael J.). (2011) Structural identifiability and indistinguishability analyses of the minimal model and a euglycemic hyperinsulinemic clamp model for glucose–insulin dynamics. Computer Methods and Programs in Biomedicine, Volume 104 (Number 2). pp. 120-134. ISSN 0169-2607

Chapman, James D., Chappell, M. J. (Michael J.) and Evans, N. D.. (2011) The use of a formal sensitivity analysis on epidemic models with immune protection from maternally acquired antibodies. Computer Methods and Programs in Biomedicine, Vol.104 (No.2). pp. 37-49. ISSN 01692607

Watson, E. M., Chappell, M. J. (Michael J.), Ducrozet, F., Poucher, S. M. and Yates, J. W. T.. (2011) A new general glucose homeostatic model using a proportional-integral-derivative controller. Computer Methods and Programs in Biomedicine, Vol.102 (No.2). pp. 119-129. ISSN 0169-2607

Hattersley, J. G. (John G.), Pérez-Velázquez, J., Chappell, M. J. (Michael J.), Bearup, Daniel James, Roper, David I., Dowson, Christopher G., Bugg, Tim and Evans, N. D.. (2011) Indistinguishability and identifiability of kinetic models for the MurC reaction in peptidoglycan biosynthesis. Computer Methods and Programs in Biomedicine, Vol.104 (No.2). pp. 70-80. ISSN 01692607

2010

White, L. J., Schukken, Y. H., Dogan, Belgin, Green, Laura E., Döpfer, Dörte, Chappell, M. J. and Medley, Graham. (2010) Modelling the dynamics of intramammary E. coli infections in dairy cows: understanding mechanisms that distinguish transient from persistent infections. Veterinary Research, Vol.41 (No.2). 15 pages. ISSN 0928-4249

Zajarias-Fainsod, Daniel, Chappell, M. J. (Michael J.), Collingwood, Joanna F., Rennie, Adam, Nagaraja, Sanjoy and Wilson, Adrian J. (2010) Patient-specific modelling of blood-flow in cerebral aneurysms. In: COMSOL Conference (2010), Boston, U.S.A, Nov 17-19, 2010. Published in: Proceedings of the COMSOL Conference 2010

Atari, M. I., Chappell, M. J., Errington, Rachel J., Smith, Paul J. and Evans, N. D. (2010) A coupled kinetic-dynamic model characterising cell cycle response to an anti-cancer agent. In: 8th Central European Symposium on Pharmaceutical Technology , Graz, Austria, Sep 16 - 18, 2010. Published in: Scientia Pharmaceutica , Vol.78 (No.3). p. 718.

Stovin, V. R., Guymer, I., Chappell, M. J. (Michael J.) and Hattersley, J. G. (John G.). (2010) The use of deconvolution techniques to identify the fundamental mixing characteristics of urban drainage structures. Water Science and Technology, Vol.61 (No.8). pp. 2075-2081. ISSN 0273-1223

2009

Yates, James W. T., Evans, N. D. and Chappell, M. J. (Michael J.). (2009) Structural identifiability analysis via symmetries of differential equations. Automatica, Vol.45 (No.11). pp. 2585-2591. ISSN 0005-1098

Atari, M. I., Chappell, M. J., Errington, Rachel J., Smith, Paul J. and Evans, N. D. (2009) Compartmental modelling of the breast cancer resistance protein (BCRP/ABCG2) in drug transport. In: The 9th International Conference on Systems Biology (ICSB2008), Gothenburg, Sweden, Aug 22-28, 2008. Published in: 9th International Conference on Systems Biology 2008 (ICSB 2008): Abstract Book

Bearup, Daniel James, Evans, N. D., Dowson, Christopher G. and Chappell, M. J. (Michael J.) (2009) Use of structural identifiability analysis to inform experimental design for enzyme kinetics. In: The 9th International Conference on Systems Biology (ICSB2008), Gothenburg, Sweden, Aug 22-28, 2008. Published in: 9th International Conference on Systems Biology 2008 (ICSB 2008): Abstract Book

Watson, E. M., Poucher, S. M., Chappell, M. J. (Michael J.) and Teague, J. (2009) Short term and long term disease mathematical modelling of diabetes in Zucker and ZDF rats. In: 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Vienna, Austria, September 30-October 02, 2009. Published in: Diabetologia, Vol.52 (Suppl. 1). S240-S240.

Hattersley, J. G. (John G.), Evans, N. D., Chappell, M. J. (Michael J.), Mead, Graham P. and Hutchison, Colin A. (2009) Nonparametric prediction of free-light chain generation in multiple myeloma patients. In: 17th International Federation of Automatic Control World Congress (IFAC), Seoul, Republic of Korea, Jul 6-11, 2008. Published in: Proceedings of the 17th IFAC World Congress, 2008, Vol.17 (Part 1). pp. 8091-8096.

Pérez-Velázquez, J., Evans, N. D., Chappell, M. J., Errington, R, Smith, Paul J. and Khan, I. (2009) A mathematical model of cyclin B1 dynamics at the single cell level in osteosarcoma cells. In: 17th International Federation of Automatic Control World Congress (IFAC), Seoul, Republic of Korea, Jul 6-11, 2008. Published in: Proceedings of the 17th IFAC World Congress, 2008, Vol.17 (Part 1). pp. 9057-9062.

Hutchison, Colin A., Bradwell, Arthur R., Cook, Mark, Basnayake, Kolitha, Basu, Supratik, Harding, Stephen, Hattersley, J. G. (John G.), Evans, N. D., Chappell, M. J. (Michael J.), Sampson, Paul, Foggensteiner, Lukas, Adu, Dwomoa and Cockwell, Paul. (2009) Treatment of acute renal failure secondary to multiple myeloma with chemotherapy and extended high cut-off hemodialysis. Clinical Journal of the American Society of Nephrology, Vol.4 (No.4). pp. 745-754. ISSN 1555-9041

2008

Cheung, S. Y. Amy, Evans, N. D., Chappell, M. J., Godfrey, Keith, Smith, Paul J. and Errington, Rachel J.. (2008) Exploration of the intercellular heterogeneity of topotecan uptake into human breast cancer cells through compartmental modelling. Mathematical Biosciences, Vol.213 (No.2). pp. 119-134. ISSN 0025-5564

Chappell, M. J., Evans, N. D., Errington, Rachel J., Khan, I. A., Campbell, L., Ali, Reza, Godfrey, Keith and Smith, Paul J.. (2008) A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan. Computer Methods and Programs in Biomedicine, Vol.89 (No.2). pp. 169-178. ISSN 0169-2607

Evans, N. D. and Chappell, M. J. (Michael J.) (2008) Observability normal form approach to structural identifiability analysis: application to biomedical systems models. In: European Conference on Mathematical and Theoretical Biology (ECMTB08), Edinburgh, Scotland, June 29 - July 4, 2008

2007

Hutchison, Colin A., Cockwell, Paul, Reid, Steven, Chandler, Katie, Mead, Graham P., Harrison, John, Hattersley, J. G. (John G.), Evans, N. D., Chappell, M. J. (Michael J.), Cook, Mark, Goehl, Hermann, Storr, Markus and Bradwell, Arthur R.. (2007) Efficient removal of immunoglobulin free light chains by hemodialysis for multiple myeloma: in vitro and in vivo studies. Journal of the American Society of Nephrology, Vol.18 (No.3). pp. 886-895. ISSN 1046-6673

Yates, James W. T., Chappell, M. J. and Gardner, J. W.. (2007) Novel phenomena-based dynamic model of carbon black/composite vapour sensors. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol.463 (No.2078). pp. 551-568. ISSN 1364-5021

Ali, Reza, Evans, N. D., Campbell, Lee, Errington, Rachel J., Godfrey, Keith R., Smith, Paul J. and Chappell, M. J. (2007) Modelling the control of cell proliferation by an anti-cancer agent. Measurement & Control, Vol.40 (No.1). pp. 12-15. ISSN 0020-2940

2006

Hutchison, Colin A., Cockwell, Paul, Reid, Steven, Chandler, Katie, Mead, Graham P., Harrison, John, Hattersley, J. G. (John G.), Evans, N. D., Chappell, M. J. (Michael J.), Cook, Mark, Goehl, Hermann, Storr, Markus and Bradwell, Arthur R. (2006) Efficient removal of immunoglobulin free light chains by hemodialysis in multiple myeloma: In-vitro and in-vivo studies. In: 48th Annual Meeting of the American-Society-of-Hematology, Orlando, FL, DEC 09-12, 2006. Published in: BLOOD, 108 (11 Part 2). 367B-368B.

Hutchison, C. A., Cockwell, P., Reid, S. D., Chandler, K. L., Millard, J. L., Mead, G. P., Evans, N. D., Chappell, M. J. (Michael J.) and Bradwell, A. R. (2006) Removal of serum free light chains by hemodialysis in patients with multiple myeloma. In: 58th Annual Meeting of the American-Association-of-Clinical-Chemistry, Chicago, IL, JUL 23-27, 2006. Published in: Clinical Chemistry, Volume 52 (Number 6 Suppl. S). A27-A27.

White, L. J., Lam, T. J. G. M., Schukken, Y. H., Green, Laura E., Medley, Graham and Chappell, M. J. (2006) The transmission and control of mastitis in dairy cows: A theoretical approach. In: Meeting of the Society for Veterinary Epidemiology and Preventive Medicine, Warwick, England, 2003. Published in: Preventive Veterinary Medicine, Vol.74 (No.1). pp. 67-83.

2003

Yates, J. W. T., Gardner, J. W., Chappell, M. J. (Michael J.), Bolt, F., Beeby, L. and Dowson, Christopher G. (2003) Chemical sensor screening of blood samples : robust analysis via data set reduction. In: 5th IFAC Symposium on Modelling and Control in Biomedical Systems, Melbourne, Australia, 21-23 Aug 2003. Published in: Modellling and Control in Biomedical Systems 2003 (including Biology Systems) pp. 289-294.

2001

White, L. J., Schukken, Y. H., Lam, T. J. G. M., Medley, Graham and Chappell, M. J.. (2001) A multispecies model for the transmission and control of mastitis in dairy cows. Epidemiology and Infection, Vol.127 (No.3). pp. 567-576. ISSN 0950-2688