2017

Janzén, David, Jirstrand, Mats, Chappell, M. J. (Michael J.) and Evans, Neil D. (2017) Extending existing structural identifiability analysis methods to mixed-effects models. Mathematical Biosciences, 295 . pp. 1-10. doi:10.1016/j.mbs.2017.10.009

Bergenholm, Linnéa, Parkinson, J., Mettetal, J., Evans, Neil D., Chappell, M. J. (Michael J.) and Collins, T. (2017) Predicting QRS and PR interval prolongations in humans using nonclinical data. British Journal of Pharmacology, 174 (19). pp. 3268-3283. doi:10.1111/bph.13940

Trägårdh, Magnus, Chappell, M. J. (Michael J.), Palm, Johan E., Evans, Neil D., Janzén, David and Gennemark, Peter (2017) Input estimation for extended-release formulations exemplified with exenatide. Frontiers in Bioengineering and Biotechnology , 5 . doi:10.3389/fbioe.2017.00024

Wong, Hin Kwan, Tiffin, Paul A., Chappell, M. J. (Michael J.), Nichols, Thomas E., Welsh, Patrick R., Doyle, Orla M., Lopez Kolkovska, Boryana Cristina, Inglis, Sarah K., Coghill, David, Shen, Yuan and Tiño, Peter (2017) Personalized medication response prediction for attention-deficit hyperactivity disorder : learning in the model space vs. learning in the data space. Frontiers in Physiology, 8 . 199. doi:10.3389/fphys.2017.00199

Kendrick, Felicity, Evans, Neil D., Arnulf, Bertrand, Avet-Loiseau, Hervé, Decaux, Olivier, Dejoie, Thomas, Fouquet, Guillemette, Guidez, Stéphanie, Harel, Stéphanie, Hebraud, Benjamin, Javaugue, Vincent, Richez, Valentine, Schraen, Susanna, Touzeau, Cyrille, Moreau, Philippe, Leleu, Xavier, Harding, Stephen and Chappell, M. J. (Michael J.) (2017) Analysis of a compartmental model of endogenous immunoglobulin G metabolism with application to multiple myeloma. Frontiers in Physiology, 8 . 149. doi:10.3389/fphys.2017.00149

2016

Janzén, David, Bergenholm, Linnéa, Jirstrand, Mats, Parkinson, Joanna, Yates, James, Evans, Neil D. and Chappell, M. J. (Michael J.) (2016) Parameter identifiability of fundamental pharmacodynamic models. Frontiers in Physiology, 7 . 590. doi:10.3389/fphys.2016.00590

Chatzistefani, Nefeli, Chappell, M. J. (Michael J.), Hutchinson, Charles E., Kletzenbauer, S. and Evans, Neil D. (2016) A mathematical model characterising Achilles tendon dynamics in flexion. Mathematical Biosciences . doi:10.1016/j.mbs.2016.11.006 (In Press)

Janzén, David, Jirstrand, Mats, Chappell, M. J. (Michael J.) and Evans, Neil D. (2016) Three novel approaches to structural identifiability analysis in mixed-effects models. Computer Methods and Programs in Biomedicine . doi:10.1016/j.cmpb.2016.04.024

Bergenholm, Linnéa, Collins, Teresa, Evans, Neil D., Chappell, M. J. (Michael J.) and Parkinson, Joanna (2016) PKPD modelling of PR and QRS intervals in conscious dogs using standard safety pharmacology data. Journal of Pharmacological and Toxicological Methods, 79 . pp. 34-44. doi:10.1016/j.vascn.2016.01.002

Boger, Elin, Evans, Neil D., Chappell, M. J. (Michael J.), Lundqvist, A., Ewing, P., Wigenborg, A. and Friden, M. (2016) Systems pharmacology approach for prediction of pulmonary and systemic pharmacokinetics and receptor occupancy of inhaled drugs. CPT : Pharmacometrics & Systems Pharmacology, 5 (4). pp. 201-210. doi:10.1002/psp4.12074

Trägårdh, Magnus, Chappell, M. J. (Michael J.), Ahnmark, Andrea, Lindén, Daniel, Evans, Neil D. and Gennemark, Peter (2016) Input estimation for drug discovery using optimal control and Markov chain Monte Carlo approaches. Journal of Pharmacokinetics and Pharmacodynamics, 43 (2). pp. 207-221. doi:10.1007/s10928-016-9467-z

Andersson, Robert, Jirstrand, Mats, Peletier, Lambertus, Chappell, M. J. (Michael J.), Evans, Neil D. and Gabrielsson, Johan (2016) Dose–response-time modelling : second-generation turnover model with integral feedback control. European Journal of Pharmaceutical Sciences, 81 . pp. 189-200. doi:10.1016/j.ejps.2015.10.018

2015

Janzén, David, Jirstrand, Mats, Evans, Neil D. and Chappell, M. J. (Michael J.) (2015) Structural identifiability in mixed-effects models : two different approaches. IFAC-PapersOnLine, 48 (20). pp. 563-568. doi:10.1016/j.ifacol.2015.10.201

Collins, Teresa, Bergenholm, Linnéa, Abdulla, Tariq, Yates, J. W. T., Evans, Neil D., Chappell, M. J. (Michael J.) and Mettetal, J. T. (2015) Modeling and simulation approaches for cardiovascular function and their role in safety assessment. CPT : Pharmacometrics & Systems Pharmacology, 4 (3). pp. 175-188. doi:DOI: 10.1002/psp4.18

Boger, Elin, Ewing, P., Eriksson, U. G., Fihn, B.-M., Chappell, M. J. (Michael J.), Evans, Neil D. and Friden, M. (2015) A novel in vivo receptor occupancy methodology for the glucocorticoid receptor : towards an improved understanding of lung PK/PD. Journal of Pharmacology and Experimental Therapeutics . doi:10.1124/jpet.114.221226 (In Press)

2014

Vincent, Timothy A., Wilson, A., Hattersley, John G., Chappell, M. J. (Michael J.) and Gardner, J. W. (2014) Design and modelling of a portable breath analyser for metabolic rate measurement. Procedia Engineering, Volume 87 . pp. 668-671. doi:10.1016/j.proeng.2014.11.576

Braddick, Darren, Sandhu, Sandeep, Roper, David I., Chappell, M. J. (Michael J.) and Bugg, Tim (2014) Observation of the time-course for peptidoglycan lipid intermediate II polymerization by Staphylococcus aureus monofunctional transglycosylase. Microbiology, Volume 160 (Part 8). pp. 1628-1636. doi:10.1099/mic.0.079442-0

Grandjean, Thomas R. B., Chappell, M. J. (Michael J.), Yates, James W. T. and Evans, Neil D. (2014) Structural identifiability analyses of candidate models for in vitro Pitavastatin hepatic uptake. Computer Methods and Programs in Biomedicine, Volume 114 (Number 3). e60-e69. doi:10.1016/j.cmpb.2013.06.013

2013

Hall, Adam J., Chappell, M. J. (Michael J.), Aston, John A. D. and Ward, Stephen A. (2013) Pharmacokinetic modelling of the anti-malarial drug artesunate and its active metabolite dihydroartemisinin. Computer Methods and Programs in Biomedicine . doi:10.1016/j.cmpb.2013.05.010

Hattersley, John G., Chappell, M. J. (Michael J.), Zehnder, Daniel, Higgins, Rob and Evans, Neil D. (2013) Describing the effectiveness of immunosuppression drugs and apheresis in the treatment of transplant patients. Computer Methods and Programs in Biomedicine, Volume 109 (Number 2). pp. 126-133. doi:10.1016/j.cmpb.2011.12.013

Bearup, Daniel J., Evans, Neil D. and Chappell, M. J. (Michael J.) (2013) The input–output relationship approach to structural identifiability analysis. Computer Methods and Programs in Biomedicine, Volume 109 (Number 2). pp. 171-181. doi:10.1016/j.cmpb.2012.10.012

Evans, Neil D., Moyse, Harry, Lowe, David Philip, Briggs, D., Higgins, Rob, Mitchell, Daniel A., Zehnder, Daniel and Chappell, M. J. (Michael J.) (2013) Structural identifiability of surface binding reactions involving heterogeneous analyte : application to surface plasmon resonance experiments. Automatica, Volume 49 (Number 1). pp. 48-57. doi:10.1016/j.automatica.2012.09.015

2012

Grandjean , T. R., Yates, J. T. W. and Chappell, M. J. (Michael J.) (2012) Compartmental modelling of in vivo drug interaction in hepatic uptake. In: PKUK Conference 2012, Nov 2012. Published in: Pharmacokinetics UK (PKUK) (Unpublished)

Moyse, Harry, Lowe, David Philip, Briggs, D., Higgins, Rob, Bentall, A., Ball, S., Mitchell, Daniel A., Chappell, M. J. (Michael J.), Zehnder, Daniel and Evans, Neil D. (2012) Estimation of antibody binding affinities with surface plasmon resonance experiments in incompatible blood type renal transplants. In: 8th IFAC Symposium on Biological and Medical Systems, Budapest, Hungary, 29-31 Aug 2012. Published in: Biological and Medical Systems, Volume 8 (Number 1). pp. 97-102. ISBN 9783902823106. ISSN 1474-6670. doi:10.3182/20120829-3-HU-2029.00088

Keir, R., Evans, Neil D., Hutchison, C. A., Vigano, M. R., Stella, A., Fabbrini, P., Storr, M. and Chappell, M. J. (Michael J.) (2012) Kinetic modelling of haemodialysis removal of myoglobin in rhabdomyolysis patients. In: 8th IFAC Symposium on Biological and Medical Systems, Budapest, Hungary, 29-31 Aug 2012. Published in: Biological and Medical Systems, Volume 8 (Number 1). pp. 284-289. ISBN 9783902823106. ISSN 1474-6670. doi:10.3182/20120829-3-HU-2029.00057

Grandjean, Thomas R. B., Chappell, M. J. (Michael J.), Yates, J. T. W. and Evans, Neil D. (2012) Structural identifiability and indistinguishability analyses of in vitro pitavastatin hepatic uptake. In: 8th IFAC Symposium on Biological and Medical Systems, Budapest, Hungary, 29-31 Aug 2012. Published in: Biological and Medical Systems, Volume 8 (Number 1). pp. 361-366. ISSN 1474-6670. doi:10.3182/20120829-3-HU-2029.00087

2011

Grandjean, Thomas R. B., Chappell, M. J. (Michael J.), Yates, J. W. T., Jones, Kevin, Wood, Gemma and Coleman, Tanya (2011) Compartmental modelling of the pharmacokinetics of a breast cancer resistance protein. Computer Methods and Programs in Biomedicine, Vol.104 (No.2). pp. 81-92. doi:10.1016/j.cmpb.2010.08.018

Atari, M. I., Chappell, M. J. (Michael J.), Errington, Rachel J., Smith, Paul J. and Evans, Neil D. (2011) Kinetic modelling of the role of the aldehyde dehydrogenase enzyme and the breast cancer resistance protein in drug resistance and transport. Computer Methods and Programs in Biomedicine, Vol.104 (No.2). pp. 93-103. doi:10.1016/j.cmpb.2010.06.008

Chin, Sze Vone and Chappell, M. J. (Michael J.) (2011) Structural identifiability and indistinguishability analyses of the minimal model and a euglycemic hyperinsulinemic clamp model for glucose–insulin dynamics. Computer Methods and Programs in Biomedicine, Volume 104 (Number 2). pp. 120-134. doi:10.1016/j.cmpb.2010.08.012

Chapman, James D., Chappell, M. J. (Michael J.) and Evans, Neil D. (2011) The use of a formal sensitivity analysis on epidemic models with immune protection from maternally acquired antibodies. Computer Methods and Programs in Biomedicine, Vol.104 (No.2). pp. 37-49. doi:10.1016/j.cmpb.2010.08.019

Watson, E. M., Chappell, M. J. (Michael J.), Ducrozet, F., Poucher, S. M. and Yates, J. W. T. (2011) A new general glucose homeostatic model using a proportional-integral-derivative controller. Computer Methods and Programs in Biomedicine, Vol.102 (No.2). pp. 119-129. doi:10.1016/j.cmpb.2010.08.013

Hattersley, John G., Pérez-Velázquez, J., Chappell, M. J. (Michael J.), Bearup, Daniel James, Roper, David I., Dowson, Christopher G., Bugg, Tim and Evans, Neil D. (2011) Indistinguishability and identifiability of kinetic models for the MurC reaction in peptidoglycan biosynthesis. Computer Methods and Programs in Biomedicine, Vol.104 (No.2). pp. 70-80. doi:10.1016/j.cmpb.2010.07.009

2010

White, L. J., Schukken, Y. H., Dogan, Belgin, Green, Laura E., Döpfer, Dörte, Chappell, M. J. (Michael J.) and Medley, Graham (2010) Modelling the dynamics of intramammary E. coli infections in dairy cows: understanding mechanisms that distinguish transient from persistent infections. Veterinary Research, Vol.41 (No.2). 15 pages. doi:10.1051/vetres/2009061

Zajarias-Fainsod, Daniel, Chappell, M. J. (Michael J.), Collingwood, Joanna F., Rennie, Adam, Nagaraja, Sanjoy and Wilson, Adrian J. (2010) Patient-specific modelling of blood-flow in cerebral aneurysms. In: COMSOL Conference (2010), Boston, U.S.A, Nov 17-19, 2010. Published in: Proceedings of the COMSOL Conference 2010

Atari, M. I., Chappell, M. J. (Michael J.), Errington, Rachel J., Smith, Paul J. and Evans, Neil D. (2010) A coupled kinetic-dynamic model characterising cell cycle response to an anti-cancer agent. In: 8th Central European Symposium on Pharmaceutical Technology , Graz, Austria, Sep 16 - 18, 2010. Published in: Scientia Pharmaceutica , Vol.78 (No.3). p. 718. ISSN 0036-8709. doi:10.3797/scipharm.cespt.8.POT03

Stovin, V. R., Guymer, I., Chappell, M. J. (Michael J.) and Hattersley, John G. (2010) The use of deconvolution techniques to identify the fundamental mixing characteristics of urban drainage structures. Water Science and Technology, Vol.61 (No.8). pp. 2075-2081. doi:10.2166/wst.2010.134

2009

Yates, James W. T., Evans, Neil D. and Chappell, M. J. (Michael J.) (2009) Structural identifiability analysis via symmetries of differential equations. Automatica, Vol.45 (No.11). pp. 2585-2591. doi:10.1016/j.automatica.2009.07.009

Atari, M. I., Chappell, M. J. (Michael J.), Errington, Rachel J., Smith, Paul J. and Evans, Neil D. (2009) Compartmental modelling of the breast cancer resistance protein (BCRP/ABCG2) in drug transport. In: The 9th International Conference on Systems Biology (ICSB2008), Gothenburg, Sweden, Aug 22-28, 2008. Published in: 9th International Conference on Systems Biology 2008 (ICSB 2008): Abstract Book

Bearup, Daniel James, Evans, Neil D., Dowson, Christopher G. and Chappell, M. J. (Michael J.) (2009) Use of structural identifiability analysis to inform experimental design for enzyme kinetics. In: The 9th International Conference on Systems Biology (ICSB2008), Gothenburg, Sweden, Aug 22-28, 2008. Published in: 9th International Conference on Systems Biology 2008 (ICSB 2008): Abstract Book

Watson, E. M., Poucher, S. M., Chappell, M. J. (Michael J.) and Teague, J. (2009) Short term and long term disease mathematical modelling of diabetes in Zucker and ZDF rats. In: 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Vienna, Austria, September 30-October 02, 2009. Published in: Diabetologia, Vol.52 (Suppl. 1). S240-S240. ISSN 0012-186X.

Hattersley, John G., Evans, Neil D., Chappell, M. J. (Michael J.), Mead, Graham P. and Hutchison, Colin A. (2009) Nonparametric prediction of free-light chain generation in multiple myeloma patients. In: 17th International Federation of Automatic Control World Congress (IFAC), Seoul, Republic of Korea, Jul 6-11, 2008. Published in: Proceedings of the 17th IFAC World Congress, 2008, Vol.17 (Part 1). pp. 8091-8096. ISSN 1474-6670. doi:10.3182/20080706-5-KR-1001.01366

Pérez-Velázquez, J., Evans, Neil D., Chappell, M. J. (Michael J.), Errington, R, Smith, Paul J. and Khan, I. (2009) A mathematical model of cyclin B1 dynamics at the single cell level in osteosarcoma cells. In: 17th International Federation of Automatic Control World Congress (IFAC), Seoul, Republic of Korea, Jul 6-11, 2008. Published in: Proceedings of the 17th IFAC World Congress, 2008, Vol.17 (Part 1). pp. 9057-9062. ISSN 1474-6670. doi:10.3182/20080706-5-KR-1001.01529

Hutchison, Colin A., Bradwell, Arthur R., Cook, Mark, Basnayake, Kolitha, Basu, Supratik, Harding, Stephen, Hattersley, John G., Evans, Neil D., Chappell, M. J. (Michael J.), Sampson, Paul, Foggensteiner, Lukas, Adu, Dwomoa and Cockwell, Paul (2009) Treatment of acute renal failure secondary to multiple myeloma with chemotherapy and extended high cut-off hemodialysis. Clinical Journal of the American Society of Nephrology, Vol.4 (No.4). pp. 745-754. doi:10.2215/CJN.04590908

Grandjean, Thomas R. B., Chappell, M. J. (Michael J.), Yates, James, Jones, Kevin, Coleman, Tanya and Wood, Gemma (2009) Compartmental modelling of the pharmacokinetics of a breast cancer resistance protein. In: 7th IFAC Symposium on Modelling and Control in Biomedical Systems, Hvide Hus, Denmark. Published in: Modeling and Control in Biomedical Systems, 7 (1). pp. 115-120. ISSN 1474-6670. doi:10.3182/20090812-3-DK-2006.00020

2008

Cheung, S. Y. Amy, Evans, Neil D., Chappell, M. J. (Michael J.), Godfrey, Keith, Smith, Paul J. and Errington, Rachel J. (2008) Exploration of the intercellular heterogeneity of topotecan uptake into human breast cancer cells through compartmental modelling. Mathematical Biosciences, Vol.213 (No.2). pp. 119-134. doi:10.1016/j.mbs.2008.03.008

Chappell, M. J. (Michael J.), Evans, Neil D., Errington, Rachel J., Khan, I. A., Campbell, L., Ali, Reza, Godfrey, Keith and Smith, Paul J. (2008) A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan. Computer Methods and Programs in Biomedicine, Vol.89 (No.2). pp. 169-178. doi:10.1016/j.cmpb.2007.11.002

Evans, Neil D. and Chappell, M. J. (Michael J.) (2008) Observability normal form approach to structural identifiability analysis: application to biomedical systems models. In: European Conference on Mathematical and Theoretical Biology (ECMTB08), Edinburgh, Scotland, June 29 - July 4, 2008

2007

Hutchison, Colin A., Cook, Mark, Harding, Stephen, Mead, Graham, Hattersley, John G., Evans, Neil D., Chappell, M. J. (Michael J.), Cockwell, Paul and Bradwell, Arthur (2007) Mathematical modelling of free light chain removal by plasma exchange and extended hemodialysis in patients with cast nephropathy. In: Spring Clinical Meeting of the National-Kidney-Foundation, Orlando, FL, April 10-14, 2007. Published in: American Journal of Kidney Diseases, Vol.49 (No.4). B46-B46. ISSN 0272-6386.

Hutchison, Colin A., Cockwell, Paul, Reid, Steven, Chandler, Katie, Mead, Graham P., Harrison, John, Hattersley, John G., Evans, Neil D., Chappell, M. J. (Michael J.), Cook, Mark, Goehl, Hermann, Storr, Markus and Bradwell, Arthur R. (2007) Efficient removal of immunoglobulin free light chains by hemodialysis for multiple myeloma: in vitro and in vivo studies. Journal of the American Society of Nephrology, Vol.18 (No.3). pp. 886-895. doi:10.1681/ASN.2006080821

Yates, James W. T., Chappell, M. J. (Michael J.) and Gardner, J. W. (2007) Novel phenomena-based dynamic model of carbon black/composite vapour sensors. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol.463 (No.2078). pp. 551-568. doi:10.1098/rspa.2006.1776

Ali, Reza, Evans, Neil D., Campbell, Lee, Errington, Rachel J., Godfrey, Keith R., Smith, Paul J. and Chappell, M. J. (Michael J.) (2007) Modelling the control of cell proliferation by an anti-cancer agent. Measurement & Control, Vol.40 (No.1). pp. 12-15.

2006

Hutchison, Colin A., Cockwell, Paul, Reid, Steven, Chandler, Katie, Mead, Graham P., Harrison, John, Hattersley, John G., Evans, Neil D., Chappell, M. J. (Michael J.), Cook, Mark, Goehl, Hermann, Storr, Markus and Bradwell, Arthur R. (2006) Efficient removal of immunoglobulin free light chains by hemodialysis in multiple myeloma: In-vitro and in-vivo studies. In: 48th Annual Meeting of the American-Society-of-Hematology, Orlando, FL, DEC 09-12, 2006. Published in: BLOOD, 108 (11 Part 2). 367B-368B. ISSN 0006-4971.

Hutchison, C. A., Cockwell, P., Reid, S. D., Chandler, K. L., Millard, J. L., Mead, G. P., Evans, Neil D., Chappell, M. J. (Michael J.) and Bradwell, A. R. (2006) Removal of serum free light chains by hemodialysis in patients with multiple myeloma. In: 58th Annual Meeting of the American-Association-of-Clinical-Chemistry, Chicago, IL, JUL 23-27, 2006. Published in: Clinical Chemistry, Volume 52 (Number 6 Suppl. S). A27-A27. ISSN 0009-9147.

White, L. J., Lam, T. J. G. M., Schukken, Y. H., Green, Laura E., Medley, Graham and Chappell, M. J. (Michael J.) (2006) The transmission and control of mastitis in dairy cows: A theoretical approach. In: Meeting of the Society for Veterinary Epidemiology and Preventive Medicine, Warwick, England, 2003. Published in: Preventive Veterinary Medicine, Vol.74 (No.1). pp. 67-83. ISSN 0167-5877. doi:10.1016/j.prevetmed.2006.01.008

2005

Yates, J. W. T., Gardner, J. W., Dow, Crawford S. and Chappell, M. J. (Michael J.) (2005) Identification of bacterial pathogens using quadrupole mass spectrometer data and radial basis function neural networks. IEE Proceedings - Science, Measurement and Technology, 152 (3). pp. 97-102. doi:10.1049/ip-smt:20041145

2003

Yates, J. W. T., Gardner, J. W., Chappell, M. J. (Michael J.), Bolt, F., Beeby, L. and Dowson, Christopher G. (2003) Chemical sensor screening of blood samples : robust analysis via data set reduction. In: 5th IFAC Symposium on Modelling and Control in Biomedical Systems, Melbourne, Australia, 21-23 Aug 2003. Published in: Modellling and Control in Biomedical Systems 2003 (including Biology Systems) pp. 289-294. ISBN 0080441599. ISSN 0962-9505.

2001

White, L. J., Schukken, Y. H., Lam, T. J. G. M., Medley, Graham and Chappell, M. J. (Michael J.) (2001) A multispecies model for the transmission and control of mastitis in dairy cows. Epidemiology and Infection, Vol.127 (No.3). pp. 567-576. doi:10.1017/S0950268801006100

1987

Chappell, M. J. (Michael J.) (1987) Lyapunov exponents for certain stochastic flows. PhD thesis, University of Warwick.