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Journal Article

Micelli, Carmina, Dai, Yunfei, Raustad, Nicole, Isberg, Ralph R., Dowson, Christopher G., Lloyd, Adrian J., Geisinger, Edward, Crow, Allister and Roper, David I. (2023) A conserved zinc-binding site in Acinetobacter baumannii PBP2 required for elongasome-directed bacterial cell shape. Proceedings of the National Academy of Sciences of the United States of America, 120 (8). e2215237120. doi:10.1073/pnas.2215237120 ISSN 0027-8424.

Dowson, Amanda J., Lloyd, Adrian J., Cuming, Andrew C., Roper, David I., Frigerio, Lorenzo and Dowson, Christopher G. (2022) Plant peptidoglycan precursor biosynthesis : conservation between moss chloroplasts and Gram-negative bacteria. Plant Physiology, 190 (1). pp. 165-179. doi:10.1093/plphys/kiac176 ISSN 1532-2548.

Dhaonoa, Gurneet K., Kushnir, Inbar, Qimron, Udi, Roper, David I. and Sagona, Antonia P. (2022) Investigating the effect of bacteriophages on bacterial FtsZ localisation. Frontiers in Cellular and Infection Microbiology-Microbiome in Health and Disease, 12 . 863712. doi:10.3389/fcimb.2022.863712 ISSN 2235-2988.

Júnior, José Renato Pattaro, Caruso, Ícaro Putinhon, de SÑ, Jéssica Maróstica, Mezalira, Taniara Suelen, de Souza Lima, Diego, Pilau, Eduardo Jorge, Roper, David I., Fernandez, Maria Aparecida and Vicente Seixas, Flavio Augusto (2022) Characterization of secondary structure and thermal stability by biophysical methods of the D-alanyl,D-alanine ligase B protein from Escherichia coli. Protein & Peptide Letters, 29 (5). pp. 448-459. doi:10.2174/0929866529666220405104446 ISSN 0929-8665.

Ashraf, Khuram U., Nygaard, Rie, Vickery, Owen N., Erramilli, Satchal K., Herrera, Carmen M., McConville, Thomas H., Petrou, Vasileios I., Giacometti, Sabrina I., Belcher Dufrisne, Meagan, Nosol, Kamil et al.
(2022) Structural basis of lipopolysaccharide maturation by the WaaL O-antigen ligase. Nature, 604 . pp. 371-376. doi:10.1038/s41586-022-04555-x ISSN 0028-0836.

Tran, Wendy, Kusay, Ali S., Hawkins, Paige M. E., Cheung, Chen-Yi, Nagalingam, Gayathri, Pujari, Venugopal, Ford, Daniel J., Stoye, Alexander, Ochoa, Jessica L., Audette, Rebecca E. et al.
(2021) Synthetic sansanmycin analogues as potent mycobacterium tuberculosis translocase I inhibitors. Journal of Medicinal Chemistry, 64 (23). pp. 17326-17345. doi:10.1021/acs.jmedchem.1c01407 ISSN 1520-4804.

Graham, Chris L. B., Newman, Hector, Gillett, Francesca, Smart, Katie, Briggs, Nicholas, Banzhaf, Manuel and Roper, David I. (2021) A dynamic network of proteins facilitate cell envelope biogenesis in gram-negative bacteria. International Journal of Molecular Sciences, 22 (23). e12831. doi:10.3390/ijms222312831 ISSN 1422-0067.

Briggs, Nicholas, Bruce, Kevin E., Naskar, Souvik, Winkler, Malcolm E. and Roper, David I. (2021) The pneumococcal divisome : dynamic control of streptococcus pneumoniae cell division. Frontiers in Microbiology, 12 . 737396. doi:10.3389/fmicb.2021.737396 ISSN 1664-302X.

York, Anna, Lloyd, Adrian J., del Genio, Charo I., Shearer, Jonathan, Hinxman, Karen, Fritz, Konstantin, FΓΌlΓΆp, Vilmos, Dowson, Christopher G., Khalid, Syma and Roper, David I. (2021) Structure-based modeling and dynamics of MurM, a Streptococcus pneumoniae penicillin resistance determinant present at the cytoplasmic membrane. Structure, 29 (7). pp. 731-742. doi:10.1016/j.str.2021.03.001 ISSN 0969-2126.

Aggarwal, Surya D. , Lloyd, Adrian J., Yerneni, Saigopalakrishna S., Narciso, Ana Rita, Shepherd, Jennifer, Roper, David I., Dowson, Christopher G., Filipe, Sergio R and Hiller, N Luisa (2021) A molecular link between cell wall biosynthesis, translation fidelity, and stringent response in Streptococcus pneumoniae. Proceedings of the National Academy of Sciences of the United States of America, 118 (14). e2018089118. doi:10.1073/pnas.2018089118 ISSN 0027-8424.

Bryant, Jack Alfred, Morris, Faye C., Knowles, Timothy J., Maderbocus, Riyaz, Heinz, Eva, Boelter, Gabriela, Alodaini, Dema, Colyer, Adam, Wotherspoon, Peter J., Staunton, Kara A. et al.
(2020) Structure of dual BON-domain protein DolP identifies phospholipid binding as a new mechanism for protein localisation. eLife, 9 . e62614. doi:10.7554/eLife.62614 ISSN 2050-084X.

Cook, Jonathan P., Baverstock, Tyler, McAndrew, Martin B. L., Stansfeld, Phillip J., Roper, David I. and Crow, Allister (2020) Insights into intrinsic resistance and bacterial cell division from a structure of EnvC bound to the FtsX periplasmic domain. Proceedings of the National Academy of Sciences of the United States of America, 117 (45). pp. 28355-28365. doi:10.1073/pnas.2017134117 ISSN 0027-8424.

Lockey, Christine, Edwards, Richard J., Roper, David I. and Dixon, Ann M. (2020) The extracellular domain of two-component system sensor kinase VanS from streptomyces coelicolor binds Vancomycin at a newly identified binding site. Scientific Reports, 10 (1). 5727. doi:10.1038/s41598-020-62557-z ISSN 2045-2322.

Catherwood, Anita C., Lloyd, Adrian J., Tod, Julie A., Chauhan, Smita, Slade, Susan E., Walkowiak, Grzegorz P., Galley, Nicola F., Punekar, Avinash S., Smart, Katie, Rea, Dean, Evans, Neil D., Chappell, Michael J., Roper, David I. and Dowson, Christopher G. (2020) Substrate and stereochemical control of peptidoglycan cross-linking by transpeptidation by Escherichia coli PBP1B. Journal of the American Chemical Society, 142 (11). pp. 5034-5048. doi:10.1021/jacs.9b08822 ISSN 0002-7863.

Kuru, Erkin, Radkov, Atanas, Meng, Xin, Egan, Alexander, Alvarez, Laura, Dowson, Amanda, Booher, Garrett, Breukink, Eefjan, Roper, David I., Cava, Felipe, Vollmer, Waldemar, Brun, Yves and VanNieuwenhze, Michael S. (2019) Mechanisms of incorporation for D-amino acid probes that target peptidoglycan biosynthesis. ACS Chemical Biology, 14 (12). pp. 2745-2756. doi:10.1021/acschembio.9b00664 ISSN 1554-8929.

Lee, Sarah C., Collins, Richard, Lin, Yu-pin, Jamshad, Mohammed, Broughton, Claire E., Harris, Sarah A., Hanson, Benjamin S, Tognoloni, Cecilia, Parslow, Rosemary A., Terry, Ann E., Rodger, Alison, Smith, Corinne J., Edler, Karen J., Ford, Robert, Roper, David I. and Dafforn, Timothy R. (2019) Nano-encapsulated escherichia coli divisome anchor ZipA, and in complex with FtsZ. Scientific Reports, 9 (1). 18712. doi:10.1038/s41598-019-54999-x ISSN 2045-2322.

Cain, Ricky, Salimraj, Ramya, Punekar, Avinash S., Bellini, Dom, Fishwick, Colin W. G., Czaplewski, Lloyd, Scott, David J., Harris, Gemma, Dowson, Christopher G., Lloyd, Adrian J. and Roper, David I. (2019) Structure-guided enhancement of selectivity of chemical probe inhibitors targeting bacterial seryl-tRNA synthetase. Journal of Medicinal Chemistry, 62 (21). pp. 9703-9717. doi:10.1021/acs.jmedchem.9b01131 ISSN 0022-2623.

Simpson, Daniel H., Hapeshi, Alexia, Rogers, Nicola J., Brabec, Viktor, Clarkson, Guy J., Fox, David J., Hrabina, Ondrej, Kay, Gemma L., King, Andrew, Malina, Jaroslav, Millard, Andrew D., Moat, John, Roper, David I., Song, Hualong, Waterfield, Nicholas R. and Scott, Peter (2019) Metallohelices that kill Gram-negative pathogens using intracellular antimicrobial peptide pathways. Chemical Science, 10 . 9708-9720. doi:10.1039/C9SC03532J ISSN 2041-6520.

Massarweh, Ahmad, Bosco, Michael, Chantret, Isabelle, LΓ©ger, Thibaut, Jamal, Layla, Roper, David I., Dowson, Christopher G., Busca, Patricia, Bouhss, Ahmed, Gravier-Pelletier, Christine and Moore, Stuart E. H. (2019) Bacterial lipid II analogs : novel in vitro substrates for mammalian oligosaccharyl diphosphodolichol diphosphatase (DLODP) activities. Molecules, 24 (11). 2135. doi:10.3390/molecules24112135 ISSN 1420-3049.

Pollock, Naomi, Rai, Megha, Simon, Kailene S., Hesketh, Sophie J., Teo, Alvin C. K. , Parmar, Mayuriben, Sridhar, Pooja, Collins, Richard, Lee, Sarah C., Stroud, Zoe N. et al.
(2019) SMA-PAGE : a new method to examine complexes of membrane proteins using SMALP nano-encapsulation and native gel electrophoresis. Biochimica et Biophysica Acta (BBA) - Biomembranes, 186 (8). pp. 1437-1445. doi:10.1016/j.bbamem.2019.05.011 ISSN 0005-2736.

Teo, Alvin C. K. , Lee, Sarah C., Pollock, Naomi L., Stroud, Zoe, Hall, Stephen, Thakker, Alpesh, Pitt, Andrew R., Dafforn, Timothy R., Spickett, Corinne M. and Roper, David I. (2019) Analysis of SMALP co-extracted phospholipids shows distinct membrane environments for three classes of bacterial membrane protein. Scientific Reports, 9 (1). 1813 . doi:10.1038/s41598-018-37962-0 ISSN 2045-2322.

ÁbrΓ‘nyi-Balogh, PΓ©ter, Petri, LΓ‘szlΓ³, Imre, TΓ­mea, Szijj, PΓ©ter, Scarpino, Andrea, Hrast, Martina, MitroviΔ‡, Ana, Fonovič, UrΕ‘a Pečar, NΓ©meth, Krisztina, Barreteau, HΓ©lΓ¨ne, Roper, David I., HorvΓ‘ti, Kata, Ferenczy, GyΓΆrgy G, Kos, Janko, IlaΕ‘, Janez, Gobec, Stanislav and KeserΕ±, GyΓΆrgy M (2018) A road map for prioritizing warheads for cysteine targeting covalent inhibitors. European Journal of Medicinal Chemistry, 160 . pp. 94-107. doi:10.1016/j.ejmech.2018.10.010 ISSN 0223-5234.

Punekar, Avinash S., Samsudin, Firdaus, Lloyd, Adrian J., Dowson, Christopher G., Scott, David J., Khalid, Syma and Roper, David I. (2018) The role of the jaw subdomain of peptidoglycan glycosyltransferases for lipid II polymerization. The Cell Surface, 2 . pp. 54-66. doi:10.1016/j.tcsw.2018.06.002 ISSN 2468-2330.

Hrast, Martina, Jukič, Marko, Patin, Delphine, Tod, Julie, Dowson, Christopher G., Roper, David I., Barreteau, Hélène and Gobec, Stanislav (2018) In silico identification, synthesis and biological evaluation of novel tetrazole inhibitors of MurB. Chemical Biology & Drug Design, 91 (6). pp. 1101-1112. doi:10.1111/cbdd.13172 ISSN 1747-0285.

Meyer, Karen, Addy, Christine, Akashi, Satoko, Roper, David I. and Tame, Jeremy R. H. (2018) The crystal structure and oligomeric form of Escherichia coli L,D-carboxypeptidase A. Biochemical and Biophysical Research Communications, 499 (3). pp. 594-599. doi:10.1016/j.bbrc.2018.03.195 ISSN 0006-291X.

Batson, Sarah, de Chiara, Cesira, Majce, Vita, Lloyd, Adrian J., Gobec, Stanislav, Rea, Dean, FΓΌlΓΆp, Vilmos, Thoroughgood, Christopher W., Simmons, Katie J., Dowson, Christopher G., Fishwick, Colin W. G., de Carvalho, Luiz Pedro S. and Roper, David I. (2017) Inhibition of D-Ala : D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine. Nature Communications, 8 (1). 1939 . doi:10.1038/s41467-017-02118-7 ISSN 2041-1723.

Sychantha, David, Jones, Carys S., Little, Dustin J., Moynihan, Patrick J., Robinson, Howard, Galley, Nicola F., Roper, David I., Dowson, Christopher G., Howell, P. Lynne and Clarke, Anthony J. (2017) In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA). PLOS Pathogens, 13 (10). e1006667. doi:10.1371/journal.ppat.1006667 ISSN 1553-7374.

Tran, Anh T., Watson, Emma E., Pujari, Venugopal, Conroy, Trent, Dowman, Luke J., Giltrap, Andrew M., Pang, Angel, Wong, Weng-Ruh, Linington, Roger G., Saunders, Jessica, Charman, Susan A., West, Nicholas P., Bugg, Tim, Tod, Julie, Dowson, Christopher G., Roper, David I., Crick, Dean C., Britton, Warwick J. and Payne, Richard J. (2017) Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis. Nature Communications, 8 . 14414 . doi:10.1038/ncomms14414 ISSN 2041-1723.

Calvez, Philippe, Breukink, Eefjan, Roper, David I., Dib, MΓ©lanie, Contreras-Martel, Carlos and Zapun, AndrΓ© (2017) Substitutions in PBP2b from Ξ²-lactam resistant Streptococcus pneumoniae have different effects on enzymatic activity and drug reactivity. Journal of Biological Chemistry, 292 (7). pp. 2854-2865. doi:10.1074/jbc.M116.764696 ISSN 0021-9258.

Vajs, Jure, Proud, Conor, Brozovic, Anamaria, Gazvoda, Martin, Lloyd, Adrian J., Roper, David I., Osmak, Maja, KoΕ‘mrlj, Janez and Dowson, Christopher G. (2017) Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis. European Journal of Medicinal Chemistry, 127 . pp. 223-234. doi:10.1016/j.ejmech.2016.12.060 ISSN 0223-5234.

Broughton, Claire E., Berg, Hugo van den, Wemyss, Alan M., Roper, David I. and Rodger, Alison (2016) Beyond the discovery void : new targets for antibacterial compounds. Science Progress, 99 (2). pp. 153-182. doi:10.3184/003685016X14616130512308 ISSN 0036-8504.

Usha, Veeraraghavan, Lloyd, Adrian J., Roper, David I., Dowson, Christopher G., Kozlov, Guennadi, Gehring, Kalle, Chauhan, Smita, Imam, Hasan T., Blindauer, Claudia A. and Besra, Gurdyal S. (2016) Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase. Scientific Reports, 6 . 23191. doi:10.1038/srep23191 ISSN 2045-2322.

Kaner, Rebecca A., Allison, Simon A., Faulkner, Alan D., Simpson, Daniel H., Waterfield, Nicholas R., Phillips, Roger M., Roper, David I., Shepherd, Samantha L. and Scott, Peter (2016) Anticancer metallohelices : nanomolar potency and high selectivity. Chemical Science, 7 (2). pp. 951-958. doi:10.1039/c5sc03677a ISSN 2041-6520.

Broughton, Claire E., Roper, David I., Berg, Hugo van den and Rodger, Alison (2015) Bacterial cell division : experimental and theoretical approaches to the divisome. Science Progress, 98 (4). pp. 313-345. doi:10.3184/003685015X14461391862881 ISSN 0036-8504.

Teo, Alvin and Roper, David I. (2015) Core steps of membrane-bound peptidoglycan biosynthesis : recent advances, insight and opportunities. Antibiotics, 4 (4). pp. 495-520. doi:10.3390/antibiotics4040495 ISSN 2079-6382.

Zuegg, Johannes, Muldoon, Craig, Adamson, George, McKeveney, Declan, Thanh, Giang Le, Premraj, Rajaratnam, Becker, Bernd, Cheng, Mu, Elliott, Alysha G., Huang, Johnny X. et al.
(2015) Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity. Nature Communications, 6 . pp. 1-11. 7719. doi:10.1038/ncomms8719 ISSN 2041-1723.

Dow, Claire E., Berg, Hugo van den, Roper, David I. and Rodger, Alison (2015) Biological insights from a simulation model of the critical FtsZ accumulation required for prokaryotic cell division. Biochemistry, 54 (24). pp. 3803-3813. doi:10.1021/acs.biochem.5b00261 ISSN 0006-2960.

Li, Qiong, Cheng, Wang, Morlot, CΓ©cile, Bai, Xiao-Hui, Jiang, Yong-Liang, Wang, Wenjia, Roper, David I., Vernet, Thierry, Dong, Yu-Hui, Chen, Yuxing and Zhou, Cong-Zhao (2015) Full-length structure of the major autolysin LytA. Acta Crystallographica Section D Biological Crystallography, 71 (6). pp. 1373-1381. doi:10.1107/S1399004715007403 ISSN 0907-4449.

Faulkner, Alan D., Kaner, Rebecca A., Abdallah, Qasem M. A., Clarkson, Guy J., Fox, David J., Gurnani, Pratik, Howson, Suzanne E., Phillips, Roger M. , Roper, David I., Simpson, Daniel H. and Scott, Peter (2014) Asymmetric triplex metallohelices with high and selective activity against cancer cells. Nature Chemistry, Volume 6 (Number 9). pp. 797-803. doi:10.1038/nchem.2024 ISSN 1755-4330.

Braddick, Darren, Sandhu, Sandeep, Roper, David I., Chappell, M. J. (Michael J.) and Bugg, Tim (2014) Observation of the time-course for peptidoglycan lipid intermediate II polymerization by Staphylococcus aureus monofunctional transglycosylase. Microbiology, Volume 160 (Part 8). pp. 1628-1636. doi:10.1099/mic.0.079442-0 ISSN 1350-0872.

Galley, Nicola F., O'Reilly, Amy M. and Roper, David I. (2014) Prospects for novel inhibitors of peptidoglycan transglycosylase. Bioorganic Chemistry, Volume 55 (Number 100). pp. 16-26. doi:10.1016/j.bioorg.2014.05.007 ISSN 0045-2068.

Paulin, Sarah, Jamshad, Mohammed, Dafforn, Tim, Garcia-Lara, Jorge, Foster, Simon J., Galley, Nicola F., Roper, David I., Rosado, Helena and Taylor, Peter W. (2014) Surfactant-free purification of membrane protein complexes from bacteria : application to the staphylococcal penicillin-binding protein complex PBP2/PBP2a. Nanotechnology, Volume 25 (Number 28). Article number 285101. doi:10.1088/0957-4484/25/28/285101 ISSN 0957-4484.

Rodolis, Maria T., Mihalyi, Agnes, O'Reilly, Amy M., Slikas, Justinas, Roper, David I., Hancock, Robert E. W. and Bugg, Tim (2014) Identification of a novel inhibition site in Translocase MraY based upon the site of interaction with Lysis Protein E from Bacteriophage Ο•X174. Chembiochem, Volume 15 (Number 9). pp. 1300-1308. doi:10.1002/cbic.201402064 ISSN 1439-4227.

Lloyd, Adrian J., Potter, Nicola J., Fishwick, Colin W. G., Roper, David I. and Dowson, Christopher G. (2013) Adenosine Tetraphosphoadenosine drives a continuous ATP-release assay for Aminoacyl-tRNA synthetases and other Adenylate-forming enzymes. ACS Chemical Biology, 8 (10). pp. 2157-2163. doi:10.1021/cb400248f ISSN 1554-8929.

Lloyd, Adrian J., Potter, Nicola J., Fishwick, Colin W. G., Roper, David I. and Dowson, Christopher G. (2013) Adenosine tetraphosphoadenosine drives a continuous ATP-release assay for aminoacyl-tRNA synthetases and other adenylate-forming enzymes. ACS Chemical Biology, 8 (10). pp. 2157-2163. doi:10.1021/cb400248f ISSN 1554-8929.

ValegΓ₯rd, Karin, Iqbal, Aman, Kershaw, Nadia J., Ivison, David, GΓ©nΓ©reux, Catherine, Dubus, Alain, Blikstad, Cecilia, Demetriades, Marina, Hopkinson, Richard J., Lloyd, Adrian J., Roper, David I., Schofield, Christopher J., Andersson, Inger and McDonough, Michael A. (2013) Structural and mechanistic studies of theorf12 gene product from the clavulanic acid biosynthesis pathway. Acta Crystallographica Section D Biological Crystallography, Volume 69 (Number 8). pp. 1567-1579. doi:10.1107/S0907444913011013 ISSN 0907-4449.

Dow, Claire E., Rodger, Alison, Roper, David I. and Berg, Hugo van den (2013) A model of membrane contraction predicting initiation and completion of bacterial cell division. Integrative Biology (Number 5). pp. 778-795. doi:10.1039/c3ib20273a ISSN 1757-9694.

Majce, Vita, Ruane, Karen M., Gobec, Stanislav and Roper, David I. (2013) Crystallization and preliminary X-ray analysis of a UDP-MurNAc-tripeptideD-alanyl-D-alanine-adding enzyme (PaMurF) from Pseudomonas aeruginosa. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, Volume 69 (number 5). pp. 503-505. doi:10.1107/S1744309113005344 ISSN 1744-3091.

Pacheco‑GΓ³mez, RaΓΊl, Cheng, Xi, Hicks, Matthew R., Smith, Corinne J., Roper, David I., Addinall, Stephen G., Rodger, Alison and Dafforn, Tim (2013) Tetramerization of ZapA is required for FtsZ bundling. Biochemical Journal, Volume 449 (Number 3). pp. 795-802. doi:10.1042/BJ20120140 ISSN 0264-6021.

Meigh, Louise, Greenhalgh, Sophie A., Rodgers, Thomas L., Cann, Martin J., Roper, David I. and Dale, Nicholas (2013) CO2 directly modulates connexin 26 by formation of carbamate bridges between subunits. eLife, Volume 2 . Article number e01213. doi:10.7554/eLife.01213 ISSN 2050-084X.

Zapun, AndrΓ©, Philippe, Jules, Abrahams, Katherine A., Signor, Luca, Roper, David I., Breukink, Eefjan and Vernet, Thierry (2013) In vitro reconstitution of peptidoglycan assembly from the gram-positive pathogen streptococcus pneumoniae. ACS Chemical Biology, Volume 8 (Number 12). pp. 2688-2696. doi:10.1021/cb400575t ISSN 1554-8929.

Ruane, Karen M., Lloyd, Adrian J., Fülâp, Vilmos, Dowson, Christopher G., Barreteau, Hélène, Boniface, Audrey, Dementin, Sébastien, Blanot, Didier, Mengin-Lecreulx, Dominique, Gobec, Stanislav, Dessen, Andréa and Roper, David I. (2013) Specificity determinants for lysine incorporation in staphylococcus aureus peptidoglycan as revealed by the structure of a MurE enzyme ternary complex. Journal of Biological Chemistry, Volume 288 (Number 46). Article number 33439. doi:10.1074/jbc.M113.508135 ISSN 0021-9258.

Yoshida, Hisashi, Kawai, Fumihiro, Obayashi, Eiji, Akashi, Satoko, Roper, David I., Tame, Jeremy R.H. and Park, Sam-Yong (2012) Crystal structures of penicillin-binding protein 3 (PBP3) from methicillin-resistant staphylococcus aureus in the apo and cefotaxime‐bound forms. Journal of Molecular Biology, Volume 423 (Number 3). pp. 351-364. doi:10.1016/j.jmb.2012.07.012 ISSN 0022-2836.

Turner, Daniel J., Portman, Ian, Dafforn, Tim, Rodger, Alison, Roper, David I., Smith, Corinne J. and Turner, Matthew S. (2012) The Mechanics of FtsZ fibers. Biophysical Journal, Vol.102 (No.4). pp. 731-738. doi:10.1016/j.bpj.2012.01.015 ISSN 00063495.

Pacheco-GΓ³mez, RaΓΊl, Roper, David I., Dafforn, Tim and Rodger, Alison (2011) The pH dependence of polymerization and bundling by the essential bacterial cytoskeltal protein FtsZ. PLoS One, Vol.6 (No.6). e19369. doi:10.1371/journal.pone.0019369 ISSN 1932-6203.

Bugg, Tim, Braddick, Darren, Dowson, Christopher G. and Roper, David I. (2011) Bacterial cell wall assembly : still an attractive antibacterial target. Trends in Biotechnology, Vol.29 (No.4). pp. 167-173. doi:10.1016/j.tibtech.2010.12.006 ISSN 0167-7799.

Hattersley, John G., PΓ©rez-VelΓ‘zquez, J., Chappell, M. J. (Michael J.), Bearup, Daniel James, Roper, David I., Dowson, Christopher G., Bugg, Tim and Evans, Neil D. (2011) Indistinguishability and identifiability of kinetic models for the MurC reaction in peptidoglycan biosynthesis. Computer Methods and Programs in Biomedicine, Vol.104 (No.2). pp. 70-80. doi:10.1016/j.cmpb.2010.07.009 ISSN 01692607.

Batson, Sarah, Rea, Dean, FΓΌlΓΆp, Vilmos and Roper, David I. (2010) Crystallization and preliminary X-ray analysis of a D-alanyl-D-alanine ligase (EcDdlB) from Escherichia coli. Journal of Experimental Psychology: Human Perception and Performance, Vol.66 (No.4). pp. 405-408. doi:10.1107/S1744309110003970 ISSN 0096-1523.

Kawai, Fumihiro, Clarke, Thomas B., Roper, David I., Han, Gab-Jo, Hwang, Kwang Yeon, Unzai, Satoru, Obayashi, Eiji, Park, Sam-Yong and Tame, Jeremy R. H. (2010) Crystal structures of penicillin-binding proteins 4 and 5 from Haemophilus influenzae. Journal of Molecular Biology, Vol.396 (No.3). pp. 634-645. doi:10.1016/j.jmb.2009.11.055 ISSN 0022-2836.

Paradis-Bleau, Catherine, Lloyd, Adrian, Sanschagrin, Francois, Maaroufi, Halim, Clarke, Thomas B., Blewett, Ann, Dowson, Christopher G., Roper, David I., Bugg, Tim and Levesque, Roger C. (2009) Pseudomonas aeruginosa MurE amide ligase : enzyme kinetics and peptide inhibitor. Biochemical Journal, Vol.421 (No. 2). pp. 263-272. doi:10.1042/BJ20081395 ISSN 0264-6021.

Cressina, Elena, Lloyd, Adrian J., De Pascale, Gianfranco, Mok, B. James, Caddick, Stephen, Roper, David I., Dowson, Christopher G. and Bugg, Tim (2009) Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors. Bioorganic & Medicinal Chemistry, Vol.17 (No.9). pp. 3443-3455. doi:10.1016/j.bmc.2009.03.028 ISSN 0968-0896.

Usha, Veeraraghavan, Dover, Lynn G., Roper, David I., Fuetterer, Klaus and Besra, Gurdyal S. (2009) Structure of the diaminopimelate epimerase DapF from Mycobacterium tuberculosis. Acta Crystallographica Section D: Biological Crystallography, Vol.65 (No.4). pp. 383-387. doi:10.1107/S0907444909002522 ISSN 0907-4449.

Clarke, Thomas B., Kawai, Fumihiro, Park, Sam-Yong, Tame, Jeremy R. H., Dowson, Christopher G. and Roper, David I. (2009) Mutational analysis of the substrate specificity of Escherichia coli penicillin binding protein 4. Biochemistry, Vol.48 (No.12). pp. 2675-2683. doi:10.1021/bi801993x ISSN 0006-2960.

Sova, Matej, Cadez, Gasper, Turk, Samo, Majce, Vita, Polanc, Slovenko, Batson, Sarah, Lloyd, Adrian, Roper, David I., Fishwick, Colin W. G. and Gobec, Stanislav (2009) Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB). Bioorganic & Medicinal Chemistry Letters, Vol.19 (No.5). pp. 1376-1379. doi:10.1016/j.bmcl.2009.01.034 ISSN 0960-894X.

De Pascale, Gianfranco, Lloyd, Adrian J., Schouten, James A., Gilbey, Andrea M., Roper, David I., Dowson, Christopher G. and Bugg, Tim (2008) Kinetic characterization of lipid II-Ala:Alanyl-tRNA ligase (MurN) from streptococcus pneumoniae using semisynthetic aminoacyl-lipid II substrates. Journal of Biological Chemistry, Vol.283 (No.50). pp. 34571-34579. doi:10.1074/jbc.M805807200 ISSN 0021-9258.

Rea, Dean, Hovington, Rebecca, Rakus, John F., Gerlt, John A., FΓΌlΓΆp, Vilmos, Bugg, Tim and Roper, David I. (2008) Crystal structure and functional assignment of YfaU, a metal ion dependent class II aldolase from Escherichia coli K12. Biochemistry, Vol.47 (No.38). pp. 9955-9965. doi:10.1021/bi800943g ISSN 0006-2960.

Alderwick, Luke J., Dover, Lynn G., Veerapen, Natacha, Gurcha, Sudagar S., Kremer, Laurent, Roper, David I., Pathak, Ashish K., Reynolds, Robert C. and Besra, Gurdyal S. (2008) Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosis. Protein Expression and Purification, Vol.58 (No.2). pp. 332-341. doi:10.1016/j.pep.2007.11.012 ISSN 1046-5928.

Lloyd, Adrian J., Gilbey, Andrea M., Blewett, Anne M., De Pascale, Gianfranco, El Zoeiby, Ahmed, Levesque, Roger C., Catherwood, Anita C., Tomasz, Alexander, Bugg, Tim, Roper, David I. and Dowson, Christopher G. (2008) Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan. Journal of Biological Chemistry, Vol.283 (No.10). pp. 6402-6417. doi:10.1074/jbc.M708105200 ISSN 0021-9258.

Usha, Veeraraghavan, Dover, Lynn G., Roper, David I. and Besra, Gurdyal S. (2008) Characterization of Mycobacterium tuberculosis diaminopimelic acid epimerase: paired cysteine residues are crucial for racemization. FEMS Microbiology Letters, Vol.280 (No.1). pp. 57-63. doi:10.1111/j.1574-6968.2007.01049.x ISSN 0378-1097.

Rea, Dean, FΓΌlΓΆp, Vilmos, Bugg, Tim and Roper, David I. (2007) Structure and mechanism of HpcH : a metal ion dependent class II aldolase from the homoprotocatechuate degradation pathway of Escherichia coli. Journal of Molecular Biology, Vol.373 (No.4). pp. 866-876. doi:10.1016/j.jmb.2007.06.048 ISSN 0022-2836.

Lysenko, Elena S., Clarke, Thomas B., Shchepetov, Mikhail, Ratner, Adam J., Roper, David I., Dowson, Christopher G. and Weiser, Jeffrey N. (2007) Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing. PL o S Pathogens , Vol.3 (No.8). pp. 1073-1081. doi:10.1371/journal.ppat.0030118 ISSN 1553-7366.

Cressina, Elena, Lloyd, Adrian J., De Pascale, Gianfranco, Roper, David I., Dowson, Christopher G. and Bugg, Tim (2007) Adenosine phosphonate inhibitors of lipid II: Alanyl tRNA ligase MurM from Streptococcus pneumoniae. Bioorganic & Medicinal Chemistry Letters, Vol.17 (No.16). pp. 4654-4656. doi:10.1016/j.bmcl.2007.05.071 ISSN 0960-894X.

Lysenko, Elena S., Clarke, Thomas B., Shchepetov, Mikhail, Ratner, Adam J., Roper, David I., Dowson, Christopher G. and Weiser, Jeffrey N. (2007) Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing. PLoS Pathogens, Vol.3 (No.8). pp. 1073-1081. doi:10.1371/journal.ppat.0030118 ISSN 1553-7374.

Izumi, Atsushi, Rea, Dean, Adachi, Tomoko, Unzai, Satoru, Park, Sam-Yong, Roper, David I. and Tame, Jeremy R. H. (2007) Structure and mechanism of HpcG, a hydratase in the homoprotocatechuate degradation pathway of Escherichia coli. Journal of Molecular Biology, Vol.370 (No.5). pp. 899-911. doi:10.1016/j.jmb.2007.05.006 ISSN 0022-2836.

Lee, Sarah C., Stoilova-Mcphie, Svetla, Baxter, Laura, FΓΌlΓΆp, Vilmos, Henderson, Janey, Rodger, Alison, Roper, David I., Scott, David J., Smith, Corinne J. and Morgan, J. Alun W. (2007) Structural characterisation of the insecticidal toxin XptA1, reveals a 1.15 MDa tetramer with a cage-like structure. Journal of Molecular Biology, Vol.366 (No.5). pp. 1558-1568. doi:10.1016/j.jmb.2006.12.057 ISSN 0022-2836.

Adachi, Tomoko, Izumi, Atsushi, Rea, Dean, Park, Sam-Yong, Tame, Jeremy R. H. and Roper, David I. (2006) Expression, purification and crystallization of 2-oxo-hept-4-ene-1,7-dioate hydratase (HpcG) from Escherichia coli C. Acta Crystallographica Section F-Structural Biology And Crystallization Communicati, 62 (Part 10). pp. 1010-1012. doi:10.1107/S1744309106035901 ISSN 1744-3091.

Schouten, James A., Bagga, Sangeev, Lloyd, Adrian J., De Pascale, Gianfranco, Dowson, Christopher G., Roper, David I. and Bugg, Timothy D. H. (2006) Fluorescent reagents for in vitro studies of lipid-linked steps of bacterial peptidoglycan biosynthesis: derivatives of UDPMurNAc-pentapeptide containing d-cysteine at position 4 or 5. Molecular BioSystems, 2 (10). pp. 484-491. doi:10.1039/b607908c ISSN 1742-206X.

Usha, Veeraraghavan, Dover, Lynn G., Roper, David I., Lloyd, Adrian J. and Besra, Gurdyal S. (2006) Use of a codon alteration strategy in a novel approach to cloning the Mycobacterium tuberculosis diaminopimelic acid epimerase. FEMS Microbiology Letters, Volume 262 (Number 1). pp. 39-47. doi:10.1111/j.1574-6968.2006.00356.x ISSN 0378-1097.

Bugg, Timothy D. H., Lloyd, Adrian J. and Roper, David I. (2006) Phospho-MurNAc-pentapeptide translocase (MraY) as a target for antibacterial agents and antibacterial proteins. Infectious Disorders - Drug Targets, 6 (2). pp. 85-106. doi:10.2174/187152606784112128 ISSN 1871-5265.

TΓΆtemeyer, Sabine, Sheppard, Mark, Lloyd, Adrian, Roper, David I., Dowson, Christopher G., Underhill, David, Murray, Peter, Maskell, Duncan and Bryant, Clare (2006) IFN-gamma enhances production of nitric oxide from macrophages via a mechanism that depends on nucleotide oligomerization domain-2. Journal of Immunology, Vol.176 (No.8). pp. 4804-4810. ISSN 0022-1767.

Kishida, H., Unzai, Satoru, Roper, David I., Lloyd, A, Park, S.Y. and Tame, Jeremy R. H. (2006) Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, both in the native form and covalently linked to various antibiotics. Biochemistry, Vol.45 (No.3). pp. 783-792. doi:10.1021/bi051533t ISSN 0006-2960.

Besong, Gilbert E., Bostock, Julieanne M., Stubbings, Will, Chopra, Ian, Roper, David I., Lloyd, Adrian J., Fishwick, Colin W. G. and Johnson, A. Peter (2005) A de novo designed inhibitor of D-Ala-D-Ala ligase from E. coli. Angewandte Chemie (International Edition), 44 (39). pp. 6403-6406. doi:10.1002/anie.200501662 ISSN 1433-7851.

Journal Item

Dhanoa, Gurneet, Roper, David I. and Sagona, Antonia P. (2022) Investigation of the localisation of FtsZ in pathogenic E. coli upon bacteriophage addition in a human cell model as a biomarker for antibacterial agents. Access Microbiology, 4 (5). doi:10.1099/acmi.ac2021.po0314

Lloyd, Adrian J., Huyton, Trevor, Turkenburg, Johan and Roper, David I. (2004) Refinement of Haemophilus influenzae diaminopimelic acid epimerase (DapF) at 1.75 A resolution suggests a mechanism for stereocontrol during catalysis. Acta crystallographica. Section D, Biological crystallography, 60 (2). pp. 397-400. doi:10.1107/S0907444903027999

Dataset

Lockey, Christine, Edwards, Richard J., Roper, David I. and Dixon, Ann M. (2020) Data for The extracellular domain of two-component system sensor kinase VanS from streptomyces coelicolor binds Vancomycin at a newly identified binding site. [Dataset]

Kaner, Rebecca A., Allison, Simon A., Faulkner, Alan D., Simpson, Daniel H., Waterfield, Nicholas R., Phillips, Roger M., Roper, David I., Shepherd, Samantha L. and Scott, Peter (2015) Data for Anticancer metallohelices : nanomolar potency and high selectivity. [Dataset]

This list was generated on Thu Jun 1 11:06:30 2023 BST.