Huang, Chuan, Zabala, Daniel, de los Santos, Emmanuel, Song, Lijiang, Corre, Christophe, Alkhalaf, Lona M. and Challis, Gregory L. (2023) Parallelized gene cluster editing illuminates mechanisms of epoxyketone proteasome inhibitor biosynthesis. Nucleic Acids Research, 51 (3). pp. 1488-1499. doi:10.1093/nar/gkad009 ISSN 1362-4962.

Hobson, Christian, Jenner, Matthew, Jian, Xinyun, Griffiths, Daniel, Roberts, Douglas M., Rey-Carrizo, Matias and Challis, Gregory L. (2022) Diene incorporation by a dehydratase domain variant in modular polyketide synthases. Nature Chemical Biology, 18 . pp. 1410-1416. doi:10.1038/s41589-022-01127-y ISSN 1552-4469.

Petrova, Yoana D., Zhao, Jinlian, Webster, Gordon, Mullins, Alex J., Williams, Katherine, Alswat, Amal S., Challis, Gregory L., Bailey, Andy M. and Mahenthiralingam, Eshwar (2022) Cloning and expression of Burkholderia polyyne biosynthetic gene clusters in Paraburkholderia hosts provides a strategy for biopesticide development. Microbial Biotechnology, 15 (10). pp. 2547-2561. doi:10.1111/1751-7915.14106 ISSN 1751-7907.

Wang, Yongchen, Chintalapudi, Venkaiah, Gudmundsson, Haraldur G., Challis, Gregory L. and Anderson, Edward A. (2021) Synthesis of the C50 diastereomers of the C33–C51 fragment of stambomycin D. Organic Chemistry Frontiers, 9 (2). pp. 445-449. doi:10.1039/d1qo01635k ISSN 2052-4129.

Lim, Jieyan, Chintalapudi, Venkaiah, Gudmundsson, Haraldur G, Tran, Minh, Bernasconi, Alice, Blanco, Araceli, Song, Lijiang, Challis, Gregory L. and Anderson, Edward A (2021) Synthesis of the C1-C27 fragment of stambomycin D validates modular polyketide synthase-based stereochemical assignments. Organic Letters, 23 (19). pp. 7439-7444. doi:10.1021/acs.orglett.1c02650 ISSN 1523-7060.

Izoré, Thierry, Candace Ho, Y T, Kaczmarski, Joe A, Gavriilidou, Athina, Chow, Ka Ho, Steer, David L, Goode, Robert J A, Schittenhelm, Ralf B, Tailhades, Julien, Tosin, Manuela, Challis, Gregory L., Krenske, Elizabeth H, Ziemert, Nadine, Jackson, Colin J and Cryle, Max J (2021) Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity. Nature Communications, 12 (1). 2511. doi:10.1038/s41467-021-22623-0 ISSN 2041-1723.

Zhou, Shanshan, Bhukya, Hussain, Malet, Nicolas, Harrison, Peter J. , Rea, Dean, Belousoff, Matthew J., Venugopal, Hariprasad, Sydor, Paulina K., Styles, Kathryn, Song, Lijiang, Cryle, Max J., Alkhalaf, Lona M., Fülöp, Vilmos, Challis, Gregory L. and Corre, Christophe (2021) Molecular basis for control of antibiotic production by a bacterial hormone. Nature, 590 (7846). pp. 463-467. doi:10.1038/s41586-021-03195-x ISSN 0028-0836.

Challis, Gregory L., Nakou, Ioanna, Jenner, Matthew, Dashti, Yousef, Romero-Canelón, Isolda, Masschelein, Joleen and Mahenthiralingam, Eshwar (2020) Genomics-driven discovery of a novel glutarimide antibiotic from Burkholderia gladioli reveals an unusual polyketide synthase chain release mechanism. Angewandte Chemie International Edition, 59 (51). pp. 23145-23153. doi:10.1002/anie.202009007 ISSN 1433-7851.

Dashti, Yousef, Nakou, Ioanna, Mullins, Alex, Webster, Gordon, Jian, Xinyun, Mahenthiralingam, Eshwar and Challis, Gregory L. (2020) Discovery and biosynthesis of bolagladins : unusual lipodepsipeptides from Burkholderia gladioli clinical isolates. Angewandte Chemie International Edition, 59 (48). pp. 21553-21561. doi:10.1002/anie.202009110 ISSN 1433-7851.

Zhou, Shanshan, Malet, Nicolas, Song, Lijiang, Corre, Christophe and Challis, Gregory L. (2020) MmfL catalyses formation of a phosphorylated butenolide intermediate in methylenomycin furan biosynthesis. Chemical Communications, 56 (92). pp. 14443-14446. doi:10.1039/d0cc05658h ISSN 1364-548X.

Louka, Savvas, Barry, Sarah M., Heyes, Derren J., Mubarak, M. Qadri E., Ali, Hafiz Saqib, Alkhalaf, Lona M., Munro, Andrew W., Scrutton, Nigel S., Challis, Gregory L. and de Visser, Sam P. (2020) Catalytic mechanism of aromatic nitration by cytochrome P450 TxtE : involvement of a ferric-peroxynitrite intermediate. Journal of the American Chemical Society, 142 (37). pp. 15764-15779. doi:10.1021/jacs.0c05070 ISSN 0002-7863.

Becher, Paul G., Verschut, Vasiliki, Bibb, Maureen J., Bush, Matthew J., Molnár, Béla P., Barane, Elisabeth, Al-Bassam, Mahmoud M., Chandra, Govind, Song, Lijiang, Challis, Gregory L., Buttner, Mark J. and Flärdh, Klas (2020) Developmentally regulated volatiles geosmin and 2-methylisoborneol attract a soil arthropod to Streptomyces bacteria promoting spore dispersal. Nature microbiology, 5 . pp. 821-829. doi:10.1038/s41564-020-0697-x ISSN 2058-5276.

Banks, Alice M., Song, Lijiang, Challis, Gregory L., Bailey, Andy M. and Foster, Gary D. (2020) Bovistol B, bovistol D and strossmayerin : Sesquiterpene metabolites from the culture filtrate of the basidiomycete Coprinopsis strossmayeri. PLoS One, 15 (4). e0229925. doi:10.1371/journal.pone.0229925 ISSN 1932-6203.

Kosol, Simone, Gallo, Angelo, Griffiths, Daniel, Valentic, Timothy R., Masschelein, Joleen, Jenner, Matthew, de los Santos, Emmanuel L. C., Manzi, Lucio, Sydor, Paulina K., Rea, Dean, Zhou, Shanshan, Füllöp, Vilmos, Oldham, Neil J., Tsai, Shiou-Chuan, Challis, Gregory L. and Lewandowski, Józef R. (2019) Structural basis for chain release from the enacyloxin polyketide synthase. Nature Chemistry, 11 . 913-923 . doi:10.1038/s41557-019-0335-5 ISSN 1755-4330.

Masschelein, Joleen, Sydor, Paulina K., Hobson, Christian, Howe, Rhiannon, Jones, Cerith, Roberts, Douglas M., Zhong, Ling Yap, Parkhill, Julian, Mahenthiralingam, Eshwar and Challis, Gregory L. (2019) A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis. Nature Chemistry, 11 . 906-912 . doi:10.1038/s41557-019-0309-7 ISSN 1755-4330.

Kosol, Simone, Gallo, Angelo, Griffiths, Daniel, Valentic, Timothy R., Masschelein, Joleen, Jenner, Matthew, de los Santos, Emmanuel L. C., Manzi, Lucio, Sydor, Paulina K., Rea, Dean, Zhou, Shanshan, Fülöp, Vilmos, Oldham, Neil J., Tsai, Shiou-Chuan, Challis, Gregory L. and Lewandowski, Józef R. (2019) Data for Structural basis for chain release from the enacyloxin polyketide synthase. [Dataset]

Zhou, Shanshan, Song, Lijiang, Masschelein, Joleen, Sumang, Felaine A. M., Papa, Irene A., Zulaybar, Teofila O., Custodio, Aileen B., Zabala, Daniel, Alcantara, Edwin P., Emmanuel de los Santos, L. C. and Challis, Gregory L. (2019) Pentamycin biosynthesis in Philippine Streptomyces sp. S816 : cytochrome P450-catalyzed installation of the C-14 hydroxyl group. ACS Chemical Biology, 14 (6). pp. 1305-1309. doi:10.1021/acschembio.9b00270 ISSN 1554-8929.

Jenner, Matthew, Jian, Xinyun, Dashti, Yousef, Masschelein, Joleen, Hobson, Christian, Roberts, Douglas M., Jones, Cerith, Harris, Simon, Parkhill, Julian, Raja, Huzefa A., Oberlies, Nicholas H., Pearce, Cedric J., Mahenthiralingam, Eshwar and Challis, Gregory L. (2019) An unusual Burkholderia gladioli double chain-initiating nonribosomal peptide synthetase assembles ‘fungal’ icosalide antibiotics. Chemical Science, 10 (21). pp. 5489-5494. doi:10.1039/C8SC04897E ISSN 2041-6520.

Mullins, Alex J., Murray, James A. H., Bull, Matthew J., Jenner, Matthew, Jones, Cerith, Webster, Gordon, Green, Angharad E., Neill, Daniel R., Connor, Thomas R., Parkhill, Julian, Challis, Gregory L. and Mahenthiralingam, Eshwar (2019) Genome mining identifies cepacin as a plant-protective metabolite of the biopesticidal bacterium Burkholderia ambifaria. Nature microbiology, 4 . pp. 996-1005. doi:10.1038/s41564-019-0383-z ISSN 2058-5276.

Heidarian, Sheida, Mohammadipanah, Fatemeh, Maghsoudlou, Abdolvahab, Dashti, Yousef and Challis, Gregory L. (2019) Anti-microfouling Activity of Glycomyces sediminimaris UTMC 2460 on Dominant Fouling Bacteria of Iran Marine Habitats. Frontiers in Microbiology, 9 . 3148. doi:10.3389/fmicb.2018.03148 ISSN 1664-302X.

Alkhalaf, Lona M., Barry, Sarah M., Rea, Dean, Gallo, Angelo, Griffiths, Daniel, Lewandowski, Józef R., Fülöp, Vilmos and Challis, Gregory L. (2019) Binding of distinct substrate conformations enables hydroxylation of remote sties in thaxtomin D by cytochrome P450 TxtC. Journal of the American Chemical Society, 141 (1). pp. 216-222. doi:10.1021/jacs.8b08864 ISSN 0002-7863.

Kosol, Simone, Jenner, Matthew, Lewandowski, Józef R. and Challis, Gregory L. (2018) Protein–protein interactions in trans-AT polyketide synthases. Natural Product Reports, 35 (10). pp. 1097-1109. doi:10.1039/C8NP00066B ISSN 0265-0568.

Perry, Christopher, Sargeant, Jacob R., Song, Lijiang and Challis, Gregory L. (2018) Relative stereochemical assignment of C-33 and C-35 in the antibiotic gladiolin. Tetrahedron, 74 (38). pp. 5150-5155. doi:10.1016/j.tet.2018.06.060 ISSN 0040-4020 .

Perry, Christopher, de los Santos, Emmanuel L. C., Alkhalaf, Lona M. and Challis, Gregory L. (2018) Rieske non-heme iron-dependent oxygenases catalyse diverse reactions in natural product biosynthesis. Natural Product Reports, 35 (7). pp. 622-632. doi:10.1039/c8np00004b ISSN 0265-0568.

Ronan, Jade L., Kadi, Nadia, McMahon, Stephen A., Naismith, James H., Alkhalaf, Lona M. and Challis, Gregory L. (2018) Desferrioxamine biosynthesis : diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC. Philosophical Transactions of the Royal Society B: Biological Sciences, 373 (1748). doi:10.1098/rstb.2017.0068 ISSN 1471-2970.

Jenner, Matthew, Kosol, Simone, Griffiths, Daniel, Prasongpholchai, Panward, Manzi, Lucio, Barrow, Andrew S., Moses, John E., Oldham, Neil J., Lewandowski, Józef R. and Challis, Gregory L. (2018) Mechanism of intersubunit ketosynthase–dehydratase interaction in polyketide synthases. Nature Chemical Biology, 14 . pp. 270-275. doi:10.1038/nchembio.2549 ISSN 1552-4450.

Schwalen, Christopher J., Hudson, Graham A., Kosol, Simone, Mahanta, Nilkamal, Challis, Gregory L. and Mitchell, Douglas A. (2017) In vitro biosynthetic studies of bottromycin expand the enzymatic capabilities of the YcaO superfamily. Journal of the American Chemical Society, 139 (50). pp. 18154-18157. doi:10.1021/jacs.7b09899 ISSN 0002-7863.

Song, Lijiang, Jenner, Matthew, Masschelein, Joleen, Jones, Cerith, Bull, Matthew J., Harris, Simon R., Hartkoorn, Ruben C., Vocat, Anthony, Romero-Canelón, Isolda, Coupland, Paul, Webster, Gordon, Dunn, Matthew, Weiser, Rebecca, Paisey, Christopher, Cole, Stewart T., Parkhill, Julian, Mahenthiralingam, Eshwar and Challis, Gregory L. (2017) Discovery and biosynthesis of Gladiolin : a Burkholderia gladioli antibiotic with promising activity against Mycobacterium tuberculosis. Journal of the American Chemical Society, 139 (23). pp. 7974-7981. doi:10.1021/jacs.7b03382 ISSN 0002-7863.

Emmanuel de los Santos, L. C. and Challis, Gregory L. (2017) clusterTools : proximity searches for functional elements to identify putative biosynthetic gene clusters. UNSPECIFIED. Cold Spring Harbor Labs Journals. (Submitted)

Inahashi, Yuki, Zhou, Shanshan, Bibb, Maureen J., Song, Lijiang, Al-Bassam, Mahmoud M., Bibb, Mervyn J. and Challis, Gregory L. (2017) Watasemycin biosynthesis in Streptomyces venezuelae : thiazoline C-methylation by a type B radical-SAM methylase homologue. Chemical Science, 8 (4). pp. 2823-2831. doi:10.1039/c6sc03533g ISSN 2041-6520.

Awodi, U. R., Ronan, Jade L., Masschelein, Joleen, Emmanuel de los Santos, L. C. and Challis, Gregory L. (2017) Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis. Chemical Science, 8 (1). pp. 411-415. doi:10.1039/C6SC02803A ISSN 2041-6520.

Zhou, Shanshan, Alkhalaf, Lona M., Emmanuel de los Santos, L. C. and Challis, Gregory L. (2016) Mechanistic insights into class B radical-S-adenosylmethionine methylases : ubiquitous tailoring enzymes in natural product biosynthesis. Current Opinion in Chemical Biology, 35 . pp. 73-79. doi:10.1016/j.cbpa.2016.08.021 ISSN 1367-5931.

Ray, Lauren, Valentic, Timothy R., Miyazawa, Takeshi, Withall, David M., Song, Lijiang, Milligan, Jacob C., Osada, Hiroyuki, Takahashi, Shunji, Tsai, Shiou-Chuan and Challis, Gregory L. (2016) A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units. Nature Communications, 7 . 13609. doi:10.1038/ncomms13609 ISSN 2041-1723.

Thanapipatsiri, Anyarat, Gomez-Escribano, Juan Pablo, Song, Lijiang, Bibb, Maureen J., Al-Bassam, Mahmoud, Chandra, Govind, Thamchaipenet, Arinthip, Challis, Gregory L. and Bibb, Mervyn J. (2016) Discovery of unusual biaryl polyketides by activation of a silent streptomyces venezuelae biosynthetic gene cluster. Chembiochem, 17 (22). pp. 2189-2198. doi:10.1002/cbic.201600396 ISSN 1439-4227.

Zabala, Daniel, Cartwright, Joshua W., Roberts, Douglas M., Law, Brian J. C., Song, Lijiang, Samborskyy, Markiyan, Leadlay, P. F., Micklefield, Jason and Challis, Gregory L. (2016) A flavin-dependent decarboxylase–dehydrogenase–monooxygenase assembles the warhead of α,β-Epoxyketone proteasome inhibitors. Journal of the American Chemical Society, 138 (13). pp. 4342-4345. doi:10.1021/jacs.6b01619 ISSN 0002-7863.

Jenner, M., Masschelein, Joleen, Dashti, Y., Jones, C., Harris, S., Parkhill, J., Pearce, C., Mahenthiralingham, E. and Challis, G. L. (2016) Biosynthesis of a 'fungal' peptide antibiotic by Burkholderia gladioli. Planta Medica, 81 (S 01). S1-S381. doi:10.1055/s-0036-1597080 ISSN 0032-0943.

Rowe, R. A., Jones, C., Bull, M. J., Jenner, M., Song, L., Dashti, Y., Harris, S. R., Parkhill, J., Connor, T. R., Challis, G. L. and Mahenthiralingam, E. (2016) Characterisation of vietnamycin : a novel Burkholderia antibiotic targeting mupirocin-resistant methicillin-resistant Staphylococcus aureus (MRSA). Planta Medica, 81 (S 01). S1-S381. doi:10.1055/s-0036-1596684 ISSN 0032-0943.

Masschelein, Joleen, Sydor, P. K., Griffiths, D. E., Valentic, T. R., Gallo, A., Jones, C., Song, L., Tsai, S. C., Lewandowski, J. R., Mahenthiralingam, E. and Challis, G. L. (2016) Dissection and rational engineering of the biosynthetic pathway to enacyloxin, a promising anti-Gram-negative antibiotic. Planta Medica, 81 (S 01). S1-S381. doi:10.1055/s-0036-1596129 ISSN 0032-0943.

Jones, C., Bull, M. J., Jenner, M., Song, L., Dashti, Y., Harris, S. R., Parkhill, J., Connor, T. R., Challis, G. L. and Mahenthiralingam, E. (2016) Genome mining and characterisation of multiple bioactive compounds from a Burkholderia gladioli isolate collection. Planta Medica, 81 (S 01). S1-S381. doi:10.1055/s-0036-1596149 ISSN 0032-0943.

Li, Ning, Song, Lijiang, Liu, Minghao, Shang, Fei, Anderson, Zoe, Fox, David J., Challis, Gregory L. and Huang, Yingping (2015) Unique post-translational oxime formation in the biosynthesis of the azolemycin complex of novel ribosomal peptides from Streptomyces sp. FXJ1.264. Chemical Science, 7 (1). pp. 482-488. doi:10.1039/c5sc03021h ISSN 2041-6520.

Schäfer, Martin, Le, Tung B.K., Hearnshaw, Stephen J., Maxwell, Anthony, Challis, Gregory L., Wilkinson, Barrie and Buttner, Mark J. (2015) SimC7 is a novel NAD(P)H-dependent ketoreductase essential for the antibiotic activity of the DNA gyrase inhibitor simocyclinone. Journal of Molecular Biology, 427 (12). pp. 2192-2204. doi:10.1016/j.jmb.2015.03.019 ISSN 0022-2836.

Withall, David M., Haynes, Stuart W. and Challis, Gregory L. (2015) Stereochemistry and mechanism of undecylprodigiosin oxidative carbocyclization to streptorubin B by the Rieske oxygenase RedG. Journal of the American Chemical Society, 137 (24). pp. 7889-7897. doi:10.1021/jacs.5b03994 ISSN 0002-7863.

Sidda, John D., Song, Lijiang, Poon, Vincent, Al-Bassam, Mahmoud, Lazos, Orestis, Buttner, Mark J., Challis, Gregory L. and Corre, Christophe (2014) Discovery of a family of γ-aminobutyrate ureas via rational derepression of a silent bacterial gene cluster. Chemical Science, Volume 5 . pp. 86-89. doi:10.1039/c3sc52536h ISSN 2041-6520.

Challis, Gregory L. and Tsai, Shiou-Chuan (2014) Editorial : Fungal natural products themed issue. Natural Product Reports, Volume 31 (Number 10). p. 1241. doi:10.1039/c4np90033b ISSN 0265-0568.

Gubbens, Jacob, Zhu, Hua, Girard, Geneviève, Song, Lijiang, Florea, Bogdan I., Aston, Philip R. , Ichinose, Koji, Filippov, Dmitri V., Choi, Young H., Overkleeft, Herman S., Challis, Gregory L. and van Wezel, Gilles P. (2014) Natural product proteomining, a quantitative proteomics platform, allows rapid discovery of biosynthetic gene clusters for different classes of natural products. Chemistry & Biology, Volume 21 (Number 6). pp. 707-718. doi:10.1016/j.chembiol.2014.03.011 ISSN 1074-5521.

Jaspars, Marcel and Challis, Gregory L. (2014) Microbiology : a talented genus. Nature, Volume 506 (Number 7486). pp. 38-39. doi:10.1038/nature13049 ISSN 0028-0836.

Challis, Gregory L. (2014) Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways. Journal of Industrial Microbiology & Biotechnology, Volume 41 (Number 2). pp. 219-232. doi:10.1007/s10295-013-1383-2 ISSN 1367-5435.

Aigle, Bertrand, Lautru, Sylvie, Spiteller, Dieter, Dickschat, Jeroen S., Challis, Gregory L., Leblond, Pierre and Pernodet, Jean-Luc (2014) Genome mining of Streptomyces ambofaciens. Journal of Industrial Microbiology & Biotechnology, Volume 41 (Number 2). pp. 251-263. doi:10.1007/s10295-013-1379-y ISSN 1367-5435.

Song, Lijiang, Laureti, Luisa, Corre, Christophe, Leblond, Pierre, Aigle, Bertrand and Challis, Gregory L. (2014) Cytochrome P450-mediated hydroxylation is required for polyketide macrolactonization in stambomycin biosynthesis. The Journal of Antibiotics, Volume 67 (Number 1). pp. 71-76. doi:10.1038/ja.2013.119 ISSN 0021-8820.

Sidda, John D., Song, Lijiang, Poon, Vincent, Al Bassam, Mahmoud, Lazos, Orestis, Buttner, Mark J., Challis, Gregory L. and Corre, Christophe (2013) Discovery of a family of γ-aminobutyrate ureas via rational derepression of a silent bacterial gene cluster. Chemical Sciences, 5 (1). pp. 86-89. doi:10.1039/C3SC52536H ISSN 2041-6539.

Kodani, Shinya, Bicz, Joanna, Song, Lijiang, Deeth, Robert J., Ohnishi-Kameyama, Mayumi, Yoshida, Mitsuru, Ochi, Kozo and Challis, Gregory L. (2013) Structure and biosynthesis of scabichelin, a novel tris-hydroxamate siderophore produced by the plant pathogen Streptomyces scabies 87.22. Organic & Biomolecular Chemistry, Volume 11 (Number 28). pp. 4686-4694. doi:10.1039/c3ob40536b ISSN 1477-0520.

(2013) Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports, Vol.30 (No.1). pp. 108-160. doi:10.1039/c2np20085f ISSN 0265-0568.

Barry, Sarah M., Kers, Johan A, Johnson, Evan G, Song, Lijiang, Aston, Philip R. , Patel, Bhumit, Krasnoff, Stuart B, Crane, Brian R, Gibson, Donna M, Loria, Rosemary and Challis, Gregory L. (2012) Cytochrome P450–catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis. Nature Chemical Biology, Vol. 8 (No.10). pp. 814-816. doi:10.1038/nchembio.1048 ISSN 1552-4450.

Gerc, Amy J., Song, Lijiang, Challis, Gregory L., Stanley-Wall, Nicola R. and Coulthurst, Sarah J. (2012) The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin. PLoS One, Vol.7 (No.9). e44673. doi:10.1371/journal.pone.0044673 ISSN 1932-6203.

Lautru, Sylvie, Song, Lijiang, Demange, Luc, Lombès, Thomas, Galons, Hervé, Challis, Gregory L. and Pernodet, Jean-Luc (2012) A sweet origin for the key congocidine precursor 4-acetamidopyrrole-2-carboxylate. Angewandte Chemie International Edition, Volume 51 (Number 30). pp. 7454-7458. doi:10.1002/anie.201201445 ISSN 1433-7851.

Lewis, J. W., Morley, N. J., Ahmad, Mark, Challis, Gregory L., Wright, R., Bicker, R. and Morritt, D. (2012) Structural changes in freshwater fish and chironomids exposed to bacterial exotoxins. Ecotoxicology and Environmental Safety, Vol.80 . pp. 37-44. doi:10.1016/j.ecoenv.2012.02.006 ISSN 0147-6513.

Nusca, T. D., Kim, Y., Maltseva, N., Lee, J. Y., Eschenfeldt, W., Stols, L., Schofield, M. M., Scaglione, J. B., Dixon, S. D., Oves-Costales, Daniel, Challis, G. L., Hanna, P. C., Pfleger, B. F., Joachimiak, A. and Sherman, D. H. (2012) Functional and structural analysis of the siderophore synthetase AsbB through reconstitution of the petrobactin biosynthetic pathway from bacillus anthracis. Journal of Biological Chemistry, Volume 287 (Number 19). pp. 16058-16072. doi:10.1074/jbc.M112.359349 ISSN 0021-9258.

Song, Lijiang, Laureti, L., Gomez-Escribano, J. P., Fox, David J., Yeo, V., Corre, Christophe, Huang, S., Leblond, P., Aigle, B., Bibb, M. and Challis, Gregory L. (2012) Bacterial genome mining for novel natural product discovery. Planta Medica, Volume 78 (Number 11). Article number IL7. doi:10.1055/s-0032-1320194 ISSN 0032-0943.

Sydor, Paulina K. and Challis, Gregory L. (2012) Oxidative tailoring reactions catalyzed by nonheme iron-dependent enzymes : streptorubin B biosynthesis as an example. Methods in Enzymology, Volume 516 (Chapter 10). pp. 195-218. doi:10.1016/B978-0-12-394291-3.00002-2 ISSN 0076-6879.

Gomez-Escribano, Juan Pablo, Song, Lijiang, Bibb, Mervyn J. and Challis, Gregory L. (2012) Posttranslational β-methylation and macrolactamidination in the biosynthesis of the bottromycin complex of ribosomal peptide antibiotics. Chemical Science, Vol.3 (No.12). pp. 3522-3525. doi:10.1039/c2sc21183a ISSN 2041-6520.

Gomez-Escribano, Juan Pablo, Song, Lijiang, Fox, David J., Yeo, Valerie, Bibb, Mervyn J. and Challis, Gregory L. (2012) Structure and biosynthesis of the unusual polyketide alkaloid coelimycin P1, a metabolic product of the cpk gene cluster of Streptomyces coelicolor M145. Chemical Science, Volume 3 (Number 9). pp. 2716-2720. doi:10.1039/c2sc20410j ISSN 2041-6520.

Barry, Sarah M. and Challis, Gregory L. (2012) Tailoring reactions catalyzed by heme-dependent enzymes. Methods in Enzymology, Volume 516 (Chapter 9). pp. 171-194. doi:10.1016/B978-0-12-394291-3.00001-0 ISSN 0076-6879.

Barry , S. M. and Challis, Gregory L. (2012) Tailoring reactions catalyzed by heme-dependent enzymes: Spectroscopic characterization of the L-tryptophan-nitrating cytochrome P450 TxtE. Methods in Enzymology, Volume 516 (Chapter 9). pp. 171-194. doi:10.1016/B978-0-12-394291-3.00001-0 ISSN 0076-6879.

Schmelz, Stefan, Botting, Catherine H., Song, Lijiang, Kadi, Nadia, Challis, Gregory L. and Naismith, James H. (2011) Structural basis for acyl acceptor specificity in the achromobactin biosynthetic enzyme AcsD. Journal of Molecular Biology, Vol.412 (No.3). pp. 495-504. doi:10.1016/j.jmb.2011.07.059 ISSN 0022-2836.

Papireddy, Kancharla, Smilkstein, Martin, Kelly, Jane Xu, Salem, Shaimaa M., Alhamadsheh, Mamoun, Haynes, Stuart W., Challis, Gregory L. and Reynolds, Kevin A. (2011) Antimalarial activity of natural and synthetic prodiginines. Journal of Medicinal Chemistry, Volume 54 (Number 15). pp. 5296-5306. doi:10.1021/jm200543y ISSN 0022-2623.

Seipke, R. F., Song, Lijiang, Bicz, Joanna, Laskaris, Paris, Yaxley, Alice M., Challis, Gregory L. and Loria, Rosemary (2011) The plant pathogen Streptomyces scabies 87-22 has a functional pyochelin biosynthetic pathway that is regulated by TetR- and AfsR-family proteins. Microbiology, Vol.157 (No.9). pp. 2681-2693. doi:10.1099/mic.0.047977-0 ISSN 1350-0872.

Whicher, J. R., Florova, G., Sydor, Paulina K., Singh, R., Alhamadsheh, M., Challis, Gregory L., Reynolds, Kevin A. and Smith, Janet Louise (2011) Structure and function of the RedJ protein, a thioesterase from the prodiginine biosynthetic pathway in streptomyces coelicolor. Journal of Biological Chemistry, Vol.286 (No.25). pp. 22558-22569. doi:10.1074/jbc.M110.213512 ISSN 0021-9258.

Mahenthiralingam, Eshwar, Song, Lijiang, Sass, Andrea, White, J. (Judith), Wilmot, Ceri, Marchbank, Angela, Boaisha, Othman, Paine, James, Knight, D. (David) and Challis, Gregory L. (2011) Enacyloxins are products of an unusual hybrid modular polyketide synthase encoded by a cryptic burkholderia ambifaria genomic island. Chemistry & Biology, Vol.18 (No.5). pp. 665-677. doi:10.1016/j.chembiol.2011.01.020 ISSN 1074-5521.

Davis, Carol, Carberry, Stephen, Schrettl, Markus, Singh, Ishwar, Stephens, John C., Barry, Sarah M., Kavanagh, Kevin, Challis, Gregory L., Brougham, Dermot and Doyle, S. (Sean) (2011) The role of glutathione S-transferase GliG in gliotoxin biosynthesis in aspergillus fumigatus. Chemistry & Biology, Vol.18 (No.4). pp. 542-552. doi:10.1016/j.chembiol.2010.12.022 ISSN 1074-5521.

Sydor, Paulina K., Barry, Sarah M., Odulate, Olanipekun M., Barona-Gomez, Francisco, Haynes, Stuart W., Corre, Christophe, Song, Lijiang and Challis, Gregory L. (2011) Regio- and stereodivergent antibiotic oxidative carbocyclizations catalysed by Rieske oxygenase-like enzymes. Nature Chemistry, Vol.3 (No.5). pp. 388-392. doi:10.1038/nchem.1024 ISSN 1755-4330.

Laureti, L., Song, Lijiang, Huang, S., Corre, Christophe, Leblond, Pierre, Challis, Gregory L. and Aigle, B. (2011) Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens. Proceedings of the National Academy of Sciences of the United States of America, Vol.108 (No.15). pp. 6258-6263. doi:10.1073/pnas.1019077108 ISSN 0027-8424.

Bunet, R., Song, Lijiang, Mendes, M. V., Corre, Christophe, Hotel, L., Rouhier, N., Framboisier, X., Leblond, Pierre, Challis, Gregory L. and Aigle, B. (2011) Characterization and manipulation of the pathway-specific late regulator AlpW reveals streptomyces ambofaciens as a new producer of kinamycins. Journal of Bacteriology, Vol.193 (No.5). pp. 1142-1153. doi:10.1128/JB.01269-10 ISSN 0021-9193.

Malet, Nicolas, Song, Lijiang, Corre, Christophe and Challis, Gregory L. (2011) Structure-activity relationship and biosynthesis of signaling molecules controlling methylenomycin antibiotic production in Streptomyces coelicolor. American Chemical Society. Abstracts of Papers (at the National Meeting), Vol.241 (No.142-BIOL ).

Haynes, Stuart W., Sydor, Paulina K., Corre, Christophe, Song, Lijiang and Challis, Gregory L. (2011) Stereochemical elucidation of streptorubin B. Journal of the American Chemical Society, Vol.133 (No.6). pp. 1793-1798. doi:10.1021/ja109164t ISSN 0002-7863.

Haynes, Stuart W., Sydor, Paulina K., Corre, Christophe and Challis, Gregory L. (2011) Elucidation of pathways for antibiotic biosynthesis in streptomyces coelicolor A3(2). In: Wrigley, Stephen, (ed.) Functional Molecules from Natural Sources. Special publication (Royal Society of Chemistry (Great Britain)) (No.320). Cambridge: Royal Society of Chemistry, pp. 149-160. ISBN 9781847552594

Aigle, B., Bunet, R., Corre, Christophe, Garenaux, Amélie, Hotel, L., Huang, S., Laureti, L., Lautru, Sylvie, Mendes, V. M., Nezbedová, S., Nguyen, H., Song, Lijiang, Challis, Gregory L., Leblond, Pierre and Pernodet, Jean-Luc (2011) Genome-guided exploration of streptomyces ambofaciens secondary metabolism. In: Streptomyces : molecular biology and biotechnology. [Wymondham]: Caister Academic, pp. 179-194. ISBN 9781904455776

Oves-Costales , D. and Challis, Gregory L. (2011) Studies on the biosynthesis of the anthrax siderophore petrobactin. In: Wrigley, Stephen, (ed.) Functional Molecules from Natural Sources. Special publication (Royal Society of Chemistry (Great Britain)) (No.320). Cambridge: Royal Society of Chemistry, pp. 184-194. ISBN 9781847552594

Corre, Christophe, Haynes, Stuart W., Malet, Nicolas, Song, Lijiang and Challis, Gregory L. (2011) A butenolide intermediate in methylenomycin furan biosynthesis is implied by incorporation of stereospecifically C-13-labelled glycerols. Chemical Communications, Vol.46 (No.23). pp. 4079-4081. doi:10.1039/c000496k ISSN 1359-7345.

Patel, Prakash, Song, Lijiang and Challis, Gregory L. (2010) Distinct extracytoplasmic siderophore binding proteins recognize ferrioxamines and ferricoelichelin in streptomyces coelicolor A3(2). Biochemistry, Vol.49 (No.37). pp. 8033-8042. doi:10.1021/bi100451k ISSN 0006-2960.

Mahenthiralingam, Eshwar, Song, Lijiang, White, J. (Judith), Wilmot, Ceri, Sass, Andrea, Marchbank, Angela and Challis, Gregory L. (2010) Burkholderia ambifaria produces a polyketide antibiotic that inhibits Burkholderia multivorans and other Burkholderia cepacia complex species. Pediatric Pulmonology, Vol.45 (No.S33). p. 345. ISSN 8755-6863.

(2010) The Scottish Structural Proteomics Facility : targets, methods and outputs. Journal of Structural and Functional Genomics, Vol.11 (No.2). pp. 167-180. doi:10.1007/s10969-010-9090-y

(2010) The dynamic architecture of the metabolic switch in Streptomyces coelicolor. BMC Genomics, Vol.11 (Article 10). doi:10.1186/1471-2164-11-10 ISSN 1471-2164.

(2010) The dynamic architecture of the metabolic switch in Streptomyces coelicolor. BMC Genomics, 11 . p. 10. doi:DOI: 10.1186/1471-2164-11-10 ISSN 1471-2164.

Corre, Christophe and Challis, Gregory L. (2010) Exploiting genomics for new natural product discovery in prokaryotes. In: Mander, Lewis N. and Liu, Hung-wen, 1952-, (eds.) Comprehensive natural products II : chemistry and biology. Amsterdam ; Boston: Elsevier, pp. 429-453. ISBN 9780080453828

Corre, Christophe and Challis, Gregory L. (2009) New natural product biosynthetic chemistry discovered by genome mining. Natural Product Reports, Vol.26 (No.8). pp. 977-986. doi:10.1039/b713024b

(2009) Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens. Genome Biology (Online), Vol.10 (No.5). R51. doi:10.1186/gb-2009-10-5-r51 ISSN 1474-760X.

Kadi, Nadia, Oves-Costales, Daniel, Barona-Gomez, Francisco and Challis, Gregory L. (2009) Erratum : a new family of ATP-dependent oligomerization-macrocyclization biocatalysts. Nature Chemical Biology, Vol.5 (No.4). p. 266. doi:10.1038/nchembio0409-266 ISSN 1552-4450.

Barry, Sarah M. and Challis, Gregory L. (2009) Recent advances in siderophore biosynthesis. Current Opinion in Chemical Biology, Vol.13 (No.2). pp. 205-215. doi:10.1016/j.cbpa.2009.03.008

Oves-Costales, Daniel, Song, Lijiang and Challis, Gregory L. (2009) Enantioselective desymmetrisation of citric acid catalysed by the substrate-tolerant petrobactin biosynthetic enzyme AsbA. Chemical Communications (No.11). pp. 1389-1391. doi:10.1039/b823147h ISSN 1359-7345.

Zerikly, Malek and Challis, Gregory L. (2009) Strategies for the discovery of new natural products by genome mining. Chembiochem, Vol.10 (No.4). pp. 625-633. doi:10.1002/cbic.200800389 ISSN 1439-4227.

Schmelz, Stefan, Kadi, Nadia, McMahon, Stephen A., Song, Lijiang, Oves-Costales, Daniel, Oke, Muse, Liu, Huanting, Johnson, K. A. (Kenneth A.), Carter, Lester G., Botting, Catherine H., White, Malcolm F., Challis, Gregory L. and Naismith, James H. (2009) AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis. Nature Chemical Biology, Vol.5 (No.3). pp. 174-182. doi:10.1038/nchembio.145 ISSN 1552-4450.

O'Rourke, S. (Sean), Wietzorrek, Andreas, Fowler, Kay, Corre, Christophe, Challis, Gregory L. and Chater, K. F. (2009) Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor. Molecular Microbiology, Vol.71 (No.3). pp. 763-778. doi:10.1111/j.1365-2958.2008.06560.x ISSN 0950-382X.

Kadi, Nadia and Challis, Gregory L. (2009) Chapter 17 siderophore biosynthesis : a substrate specificity assay for nonribosomal peptide synthetase‐independent siderophore synthetases involving trapping of acyl‐adenylate intermediates with hydroxylamine. Methods in Enzymology, Vol.458 . pp. 431-457. doi:10.1016/S0076-6879(09)04817-4 ISSN 0076-6879.

Kadi, Nadia and Challis, Gregory L. (2009) Siderophore biosynthesis: a substrate specificity assay for nonribosomal peptide synthetase-independent siderophore synthetases involving trapping of acyl-adenylate intermediates with hydroxylamine. Methods in Enzymology, Vol.458 . pp. 431-457. doi:10.1016/S0076-6879(09)04817-4

Oves-Costales, Daniel, Kadi, Nadia and Challis, Gregory L. (2009) The long-overlooked enzymology of a nonribosomal peptide synthetase-independent pathway for virulence-conferring siderophore biosynthesis. Chemical Communications (No.43). pp. 6530-6541. doi:10.1039/b913092f

Chen, Kan, Rannulu, Nalaka S., Cai, Yang, Lane, P., Liebl, Andrea L., Rees, Bernard B., Corre, Christophe, Challis, Gregory L. and Cole, Richard B. (2008) Unusual odd-electron fragments from even-electron protonated prodiginine precursors using positive-ion electrospray tandem mass spectrometry. Journal of The American Society for Mass Spectrometry, Vol.19 (No.12). pp. 1856-1866. doi:10.1016/j.jasms.2008.08.002 ISSN 1044-0305.

Heather, Zoe, Holden, Matthew T. G., Steward, Karen F., Parkhill, Julian, Song, Lijiang, Challis, Gregory L., Robinson, C. (Carl), Davis-Poynter, Nicholas and Waller, Andrew S. (2008) A novel streptococcal integrative conjugative element involved in iron acquisition. Molecular Microbiology, Volume 70 (Number 5). pp. 1274-1292. doi:10.1111/j.1365-2958.2008.06481.x ISSN 0950-382X.

Corre, Christophe, Song, Lijiang, O'Rourke, S. (Sean), Chater, K. F. and Challis, Gregory L. (2008) 2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining. Proceedings of the National Academy of Sciences of the United States of America, Vol.105 (No.45). pp. 17510-17515. doi:10.1073/pnas.0805530105 ISSN 0027-8424.

Kadi, Nadia, Song, Lijiang and Challis, Gregory L. (2008) Bisucaberin biosynthesis : an adenylating domain of the BibC multi-enzyme catalyzes cyclodimerization of N-hydroxy-N-succinylcadaverine. Chemical Communications (No.41). pp. 5119-5121. doi:10.1039/b813029a ISSN 1359-7345.

McMahon, Stephen A., Oke, Muse, Liu, Huanting, Johnson, K. A. (Kenneth A.), Carter, Lester, Kadi, Nadia, White, Malcolm F., Challis, Gregory L. and Naismith, James H. (2008) Purification, crystallization and data collection of Pectobacterium chrysanthemi AcsD, a type A siderophore synthetase. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, Vol.64 (Pt.11). pp. 1052-1055. doi:10.1107/S1744309108032132 ISSN 1744-3091.

Oves-Costales, Daniel, Kadi, Nadia, Fogg, Mark J., Song, Lijiang, Wilson, Keith S. and Challis, Gregory L. (2008) Petrobactin biosynthesis: AsbB catalyzes condensation of spermidine with N-8-citryl-spermidine and its N-1-(3,4-dihydroxybenzoyl) derivative. Chemical Communications (No.34). pp. 4034-4036. doi:10.1039/b809353a ISSN 1359-7345.

Montgomery, Laura J. and Challis, Gregory L. (2008) Concise synthesis of key 3-polyenoyl-5-methylenefuran-2,4-dione putative intermediates in quartromicin biosynthesis. Synlett (No.14). pp. 2164-2168. doi:10.1055/s-2008-1078247 ISSN 0936-5214.

Kadi, Nadia, Arbache, Simon, Song, Lijiang, Oves-Costales, Daniel and Challis, Gregory L. (2008) Identification of a gene cluster that directs putrebactin biosynthesis in Shewanella species : PubC catalyzes cyclodimerization of N-hydroxy-N-succinyiputrescine. Journal of the American Chemical Society, Vol.130 (No.32). pp. 10458-10459. doi:10.1021/ja8027263 ISSN 0002-7863.

Challis, Gregory L. (2008) Genome mining for novel natural product discovery. Journal of Medicinal Chemistry, Vol.51 (No.9). pp. 2618-2628. doi:10.1021/jm700948z ISSN 0022-2623.

Haynes, Stuart W., Sydor, Paulina K., Stanley, Anna E., Song, Lijiang and Challis, Gregory L. (2008) Role and substrate specificity of the Streptomyces coelicolor RedH enzyme in undecylprodiginine biosynthesis. Chemical Communications (No.16). pp. 1865-1867. doi:10.1039/b801677a ISSN 1359-7345.

Mo, SangJoon, Sydor, Paulina K., Corre, Christophe, Alhamadsheh, Mamoun M., Stanley, Anna E., Haynes, Stuart W., Song, Lijiang, Reynolds, Kevin A. and Challis, Gregory L. (2008) Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis. Chemistry & Biology, Vol.15 (No.2). pp. 137-148. doi:10.1016/j.chembiol.2007.11.015 ISSN 1074-5521.

Challis, Gregory L. (2008) Mining microbial genomes for new natural products and biosynthetic pathways. Microbiology, Vol.154 (No.6). pp. 1555-1569. doi:10.1099/mic.0.2008/018523-0 ISSN 1350-0872.

Challis, Gregory L. and Hopwood, David A. (2007) Chemical biotechnology: biloactive small molecules - targets and discovery technologies. Current Opinion in Biotechnology, Vol.18 (No.6). pp. 475-477. doi:10.1016/j.copbio.2007.10.001

Kadi, Nadia, Oves-Costales, Daniel, Barona-Gomez, Francisco and Challis, Gregory L. (2007) A new family of ATP-dependent oligomerization-macrocyclization biocatalysts. Nature, Vol.3 (No.10). pp. 652-656. doi:10.1038/nchembio.2007.23 ISSN 0028-0836.

Oves-Costales, Daniel, Kadi, Nadia, Fogg, Mark J., Song, Lijiang, Wilson, Keith S. and Challis, Gregory L. (2007) Enzymatic logic of anthrax stealth siderophore biosynthesis: AsbA catalyzes ATP-Dependent condensation of citric acid and spermidine. Journal of the American Chemical Society, Vol.129 (No.27). pp. 8416-8417. doi:10.1021/ja072391o ISSN 0002-7863.

Lautru, Sylvie, Oves-Costales, Daniel, Pernodet, Jean-Luc and Challis, Gregory L. (2007) MbtH-like protein-mediated cross-talk between non-ribosomal peptide antibiotic and siderophore biosynthetic pathways in Streptomyces coelicolor M145. Microbiology, Vol.153 (No.5). pp. 1405-1412. doi:10.1099/mic.0.2006/003145-0 ISSN 1350-0872.

Haynes, Stuart W. and Challis, Gregory L. (2007) Non-linear enzymatic logic in natural product modular mega-synthases and -synthetases. Current Opinion in Drug Discovery & Development, Vol.10 (No.2). pp. 203-218.

Corre, Christophe and Challis, Gregory L. (2007) Heavy tools for genome mining. Chemistry & Biology, Volume 14 (Number 1). pp. 7-9. doi:10.1016/j.chembiol.2007.01.001

(2006) The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081. PLOS Genetics, Vol.2 (No.12). pp. 2039-2051. doi:10.1371/journal.pgen.0020206 ISSN 1553-7390.

Song, Lijiang, Barona-Gomez, Francisco, Corre, Christophe, Xiang, Longkuan, Udwary, Daniel W., Austin, Michael B., Noel, Joseph P., Moore, Bradley S. and Challis, Gregory L. (2006) Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining. Journal of the American Chemical Society, 128 (46). pp. 14754-14755. doi:10.1021/ja065247w ISSN 0002-7863.

Barona-Gomez, Francisco, Lautru, Sylvie, Francou, Francois-Xavier, Leblond, Pierre, Pernodet, Jean-Luc and Challis, Gregory L. (2006) Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877. MICROBIOLOGY-SGM, 152 (Part 11). pp. 3355-3366. doi:10.1099/mic.0.29161-0 ISSN 1350-0872.

Challis, Gregory L. (2006) Engineering Escherichia coli to produce nonribosomal peptide antibiotics. Nature, 2 (8). pp. 398-400. ISSN 1552-4450

Walton, Laura J., Corre, Christophe and Challis, Gregory L. (2006) Mechanisms for incorporation of glycerol-derived precursors into polyketide metabolites. In: Joint 8th Symposium on the Genetics and Molecular Biology of Industrial Microorganisms/8th International Conference on Biotechnology of Microbial Products, San Diego, USA, 14-18 Vov2004. Published in: Journal of Industrial Microbiology and Biotechnology, Volume 33 (Number 2). pp. 105-120. doi:10.1007/s10295-005-0026-7 ISSN 1367-5435.

Stanley, Anna E., Walton, Laura J., Zerikly, Malek Kourdi, Corre, Christophe and Challis, Gregory L. (2006) Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2 '-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis. Chemical Communications (Number 38). pp. 3981-3983. doi:10.1039/b609556a ISSN 1359-7345.

Corre, Christophe and Challis, Gregory L. (2005) Evidence for the unusual condensation of a diketide with a pentulose in the methylenomycin biosynthetic pathway of Streptomyces coelicolor A3(2). Chembiochem, Volume 6 (Number 12). pp. 2166-2170. doi:10.1002/cbic.200500243 ISSN 1439-4227.